Evidence map›Paper›PMID 41827813›Full record

ReviewCancers2026

Drug Development in Non-Oncogene-Addicted Non-Small Cell Lung Cancer.

Pedro Cruz, Cristina Boixareu, Diogo J Silva, Joshua Ting, Rayssa Sena, Steph A Pang, Stephanie Mullings, Anna Minchom

Erratum issuedAbstract readReview
In one paragraph

Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Pedro CruzDrug Development Unit, The Royal Marsden Hospital and The Institute of Cancer Research, London SM2 5GP, UK.ORCID 0000-0001-8813-0632
Cristina BoixareuDrug Development Unit, The Royal Marsden Hospital and The Institute of Cancer Research, London SM2 5GP, UK.ORCID 0000-0002-7630-3556
Diogo J SilvaDrug Development Unit, The Royal Marsden Hospital and The Institute of Cancer Research, London SM2 5GP, UK.ORCID 0000-0001-5295-6715
Joshua TingDrug Development Unit, The Royal Marsden Hospital and The Institute of Cancer Research, London SM2 5GP, UK.ORCID 0000-0001-7204-5767
Rayssa SenaDrug Development Unit, The Royal Marsden Hospital and The Institute of Cancer Research, London SM2 5GP, UK.ORCID 0009-0003-3133-1347
Steph A PangDrug Development Unit, The Royal Marsden Hospital and The Institute of Cancer Research, London SM2 5GP, UK.ORCID 0000-0002-6066-8083
Stephanie MullingsDrug Development Unit, The Royal Marsden Hospital and The Institute of Cancer Research, London SM2 5GP, UK.ORCID 0009-0000-0858-2621
Anna MinchomDrug Development Unit, The Royal Marsden Hospital and The Institute of Cancer Research, London SM2 5GP, UK.ORCID 0000-0002-9339-7101

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-oncogene-addicted non-small cell lung cancer therapy has seen major advances in recent years. New molecular targets and biomarkers have enabled the development of drugs as diverse as immunotherapies and antibody-drug conjugates, among others. With a pharmacological armamentarium so precise, phase I trials have also evolved from exclusively toxicological studies into early efficacy signal-seeking trials. Nonetheless, difficulties remain, with the frequent failure of new drugs when progressing to a phase III setting. Challenges are seen in the setting of later lines therapy (testing against docetaxel), of which there are several examples. These are being tackled with promising new drugs being developed, based on innovative biological rationales. We review the current state of the art of drug development in non-oncogene-addicted non-small cell lung cancer, including advances, new drugs and targets, challenges, and opportunities in drug development.

Indexed as

antibody–drug conjugatescarcinomaclinical trialsdrug developmentimmunotherapynon-oncogene-addicted non-small cell lung cancernon-small-cell lung

Identifiers

PMID41827813
PMCPMC12984520

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.