Evidence map›Paper›PMID 41827801›Full record

ArticleCancers2026

Effect of Healthy and Tumor-Associated Breast Adipose Tissue on Breast Cancer Cell Migration and Activation.

Iris L Holt-Kedde, Hetty Timmer-Bosscha, Frank A E Kruyt, Wendy Kelder, Bert van der Vegt, Mieke C Zwager, Carolien P Schröder, Marlous Arjaans

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Iris L Holt-KeddeDepartment of Plastic Surgery, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-0368-2508
Hetty Timmer-BosschaDepartment of Medical Oncology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Frank A E KruytDepartment of Medical Oncology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-2445-9380
Wendy KelderDepartment of Surgery, Martini Hospital Groningen, 9728 NT Groningen, The Netherlands.ORCID 0000-0002-5536-8940
Bert van der VegtDepartment of Pathology, University of Groningen, University Medical Center Groningen, 9714 GZ Groningen, The Netherlands.ORCID 0000-0002-2613-1506
Mieke C ZwagerDepartment of Pathology, University of Groningen, University Medical Center Groningen, 9714 GZ Groningen, The Netherlands.ORCID 0000-0002-4470-7628
Carolien P SchröderDepartment of Medical Oncology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Marlous ArjaansDepartment of Plastic Surgery, OLVG Medical Center, 1061 AE Amsterdam, The Netherlands.

Funding

from the Stichting De Cock-Hadders from the Stichting De Cock-Haddersthe Dutch Cancer Society grant RUG2010-4739the Mandema stipend the Mandema stipend
6 · The paper itself

Abstract

backgroundObesity is a recognized risk factor for developing breast cancer (BC), but factors involved remain unclear. We investigated if breast adipose tissue from healthy women, BRCA1/2 mutation carriers and BC patients, can stimulate BC cell line migration and activation.

methodsadipose tissue conditioned medium (ATCM), was prepared from breast adipose tissue from healthy subjects (naïve; group 1 (

resultsATCM from group 1 induced migration and filopodia activation in MCF-7 and MDA-MB-231, but not in SK-BR-3. ATCM from group 2 induced filopodia activation but no migration. ATCM from group 3 induced less migration in MCF-7 than ATCM from group 1. Higher BMI was associated with increased ATCM-induced activation in MCF-7 (group 1) and MDA-MB-231 (group 2). ATCM from group 1 and 2 showed a metabolic secretory profile, whereas group 3 showed higher pro-angiogenic and inflammatory cytokines.

conclusionsThis study shows that breast adipose tissue from healthy women, BRCA1/2 mutation carriers and BC patients, can stimulate BC cell line migration and activation. This effect is related to BC subtype and BMI. These data improve insight in adipose tissue as factor in BC development.

Indexed as

adipose tissueBRCAbreast cancerconditioned mediumobesity

Identifiers

PMID41827801
PMCPMC12985100

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.