ArticleCancers2026
Prospective Multimodal Assessment of Radiation-Induced Subclinical Cardiac Changes in Patients with Left Breast Cancer Using Hematologic Biomarkers, Echocardiography, and
Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Metabolic reprogramming in radiation-induced heart disease: the emerging role of PET imaging.Frontiers in cardiovascular medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
BACKGROUND/
objectivesThis prospective study aimed to investigate asymptomatic microscopic changes in the myocardium following postoperative radiation therapy (RT) in patients with left breast cancer using multi-medical assessment techniques.
methodsThis study included 16 left-sided breast cancer patients who received postoperative RT between January 2021 and December 2022 at our institution. Cardiac examinations were performed before RT and at 1, 12, 24, and 48 weeks after RT. We conducted comparative analyses between pre-RT and various post-RT time points, exploring correlations between changes in hematologic biomarkers, global longitudinal strain (GLS), and myocardial metabolism.
resultsInflammatory biomarkers such as the neutrophil-lymphocyte, platelet-lymphocyte, and lymphocyte-monocyte ratios changed between the pre- and post-RT periods but returned to normal levels after several months. However, troponin T and soluble suppression of tumorigenicity 2 showed sustained changes during the 1-year follow-up period. Among echocardiographic parameters, GLS_LAX showed a significant difference between pre-RT and post-RT assessments. Additionally, irradiated and non-irradiated myocardial metabolic ratios on
conclusionsThese findings suggest that subclinical myocardial changes may persist following RT, although the clinical significance of subclinical myocardial changes remains uncertain and warrants further investigation.
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Registered trials
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