Periodization in Orthobiologics Rehabilitation.

Orthobiologic treatments such as platelet-rich plasma and stem cell therapies are increasingly used to support the healing of tendons, ligaments, and joints. This perspective proposes applying periodization-a structured, progressive model borrowed from athletic training-to rehabilitation following orthobiologic interventions in order to improve functional outcomes. The framework is organized into sequential phases that align with biological stages of healing. Early phases emphasize pain control, inflammation management, and safe, controlled mobility. Rehabilitation then progresses toward gradually increasing load bearing and strength, and toward more specific exercises to promote tissue regeneration while reducing the risk of re-injury. In later phases (mesocycles), the model highlights the importance of neuroplastic adaptations for sustained functional recovery, including neurogenesis, synaptic plasticity, and functional remodeling to safer RTP for athletes. A key advantage of this approach is its adaptability: progression can be individualized according to a patient's recovery trajectory and response to loading. By aligning rehabilitation progression with intrinsic healing processes and integrating physiological and neuromuscular goals, the proposed model aims to maximize regenerative potential across both athletic and non-athletic populations. Overall, this neuroplastic periodized approach offers a practical, evidence-informed structure to guide clinicians in delivering patient-centered regenerative rehabilitation and may help standardize care after orthobiologic procedures.