ArticleTrials2026
Adaptive minute ventilation during intrahospital transport: study protocol for a randomized controlled trial.
Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundIntra-hospital transport of critically ill, mechanically ventilated patients is associated with significant physiological risks. Adaptive Minute Ventilation (AMV) is a closed-loop ventilation mode that automatically maintains target minute ventilation. While AMV has shown promise in intensive care unit settings, its performance during intrahospital transport has not yet been evaluated. This trial aims to assess the safety and efficacy of AMV compared with conventional ventilation strategies during patient transport.
methodsThis is a single-centre, open-label, randomized controlled non-inferiority trial conducted at Peking Union Medical College Hospital. Fifty adult patients receiving invasive mechanical ventilation and requiring transport will be randomly assigned (1:1) to either AMV or their pre-transport ventilation mode. The primary endpoint is the change in arterial carbon dioxide pressure (PaCO₂) from 30 min before to 10 min after transport. Secondary outcomes include changes in oxygenation index (PaO₂/FiO₂), peak airway pressure, dynamic compliance, and rapid shallow breathing index. Randomization will be performed using permuted block randomization. Both intention-to-treat and per-protocol analyses will be conducted. Missing data will be handled using multiple imputation. The study protocol has been reviewed and approved by the Ethics Committee of Peking Union Medical College Hospital (Approval No. I-25PJ0781). It was registered in the Chinese Clinical Trial Registry (ChiCTR2500109659) on 23 September 2025 as a retrospective registration. DISCUSSION: This trial will be the first randomized study to evaluate AMV during intrahospital transport of critically ill patients. The findings will address an important evidence gap in transport ventilation strategies, potentially informing clinical practice on whether AMV provides a safe and effective alternative to conventional modes. By employing a non-inferiority design and standardized transport protocols, the study seeks to generate robust and clinically relevant evidence despite its single-centre setting and relatively small sample size.
trial registrationApproved by the Ethics Committee of Peking Union Medical College Hospital (Approval No. I-25PJ0781).
trial registrationChiCTR, ChiCTR2500109659. Registered 23 September 2025, https://www.chictr.org.cn/hvshowproject.html?id=284847 .
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.