Trial reportBMC musculoskeletal disorders2026
Efficacy of BMP-2 in rotator cuff repair: a randomized controlled trial based on radiological and clinical outcomes.
Trial report in BMC musculoskeletal disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
backgroundTo develop an injectable recombinant human bone morphogenetic protein 2 (rh-BMP-2) hybrid material and evaluate its clinical efficacy in promoting tendon-bone interface healing in patients with rotator cuff injuries through clinical outcome assessments and MRI-based imaging analysis. MATERIALS AND
methodsThis study included patients with rotator cuff tears who had an inadequate response to conservative treatment. The injectable rh-BMP2 hybrid material was synthesized. Ultimately, a total of 92 patients completed the final follow-up and were included in the analysis, with 46 patients in the experimental group (receiving the BMP-2 hybrid injection) and 46 in the control group (receiving no injection).Clinical evaluations were conducted preoperatively, at 1 and 3 months postoperatively for the Visual Analog Scale (VAS), and at 3 months and 1 year postoperatively for shoulder range of motion (shoulder flexion, external rotation, internal rotation), the American Shoulder and Elbow Surgeons (ASES) score, and Constant-Murley score. At the final follow-up (1 year), the abduction strength ratio and MRI signal-to-noise quotient were recorded.
resultsAt the 1-year final follow-up, the BMP-2 group showed significantly better outcomes across multiple key measures compared to the control group. The BMP-2 group showed superior outcomes in ASES score (93.58 ± 5.21 vs. 90.68 ± 7.17, p = 0.03), Constant-Murley score (87.17 ± 5.55 vs. 83.93 ± 6.18, p = 0.01), and Shoulder flexion (168.70°±12.83° vs. 163.70°±13.12°, p = 0.05). External Rotation range was significantly better in the BMP-2 group (68.70°±12.25° vs. 62.61°±12.33°, p = 0.02). The abduction strength ratio favored the BMP-2 group (82.25%±6.55% vs. 77.63%±10.23%, p = 0.01), and the MRI signal-to-noise quotient was significantly lower in the BMP-2 group (2.03 ± 0.59 vs. 2.26 ± 0.52, p = 0.05), indicating better tendon healing quality. VAS scores at 1 months were significantly lower in the BMP-2 group (1.24 ± 0.48 vs. 1.63 ± 0.69, p = 0.00).
conclusionsThe material can sustained release BMP2, which effectively promotes tendon-bone healing after rotator cuff repair, improves the function of the affected shoulder and reduces the rate of retear. It can provide a new possibility for improving outcomes after rotator cuff repair.
trial registrationThe questionnaires and methodology of this study have been registered with the Chinese Clinical Trial Registry (Registration number: ChiCTR2600118568.Registered on 09/02/2026.Retrospectively registered).
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