Trial reportBMC cancer2026
Surface-guided radiation therapy combined with real-time position management-guided deep inspiratory breath-hold radiotherapy for left breast cancer.
Trial report in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeTo evaluate the efficacy of surface-guided radiation therapy (SGRT) combined with real-time position management (RPM)-guided deep inspiratory breath-hold (DIBH) radiotherapy for left breast cancer. MATERIALS AND
methodsTwenty patients diagnosed with breast cancer, who underwent breast-conserving surgery and subsequent DIBH radiotherapy, were randomly assigned to two treatment groups: SGRT-guided (SGRT); and combined SGRT + RPM-guided (SGRT + RPM). Recorded setup and cone beam computed tomography (CBCT) validation execution Time (T1), Beam delivery time (T2). Residual vertical setup error (VRT Error), six-dimensional (6D) setup errors, and breath-hold error (BH Error) were obtained using breath hold CBCT. Correlations between BH Error and VRT Error were analyzed. Dose reconstruction was performed using velocity-generated adaptive CT to compute per-fraction and accumulated doses, with coefficient of variation (CV) analysis used to quantify interfractional dose variations in clinical target volume (CTV) and organs at risk (OARs).
resultsThe mean (± SD) T1 and T2 times for the SGRT and SGRT + RPM groups were 452.53 ± 83.57 s vs. 299.58 ± 53.52 s (p < 0.05), and 147.85 ± 46.35 s vs. 135.3 ± 32.97 s (p > 0.05), respectively, with no statistical difference in 6D setup errors (p > 0.05). The SGRT group exhibited a mean BH Error that was 0.4 mm larger than that of the SGRT + RPM group, with a 0.7 mm reduction in stability. There was a correlation between BH Error and VRT Error in the SGRT group (r = 0.635, p < 0.05). Accumulated dose analysis revealed statistically significant decreases in CTV D98% and V95% in both groups (p < 0.05). However, maintained CTV coverage meeting clinical acceptability criteria (V95% ≥ 95%). The accumulated OARs doses demonstrated no significant differences compared with the planned doses (p > 0.05). There was no significant difference in CV values between the two groups (p > 0.05).
conclusionThe DIBH guided by SGRT + RPM simplify the radiotherapy workflow, improve the operation efficiency and breath-hold (BH) quality of patients. Simultaneously, it guaranteed alignment of the cumulative doses received by the CTV and OARs with the planned doses.
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