SynthesisBMC cancer2026
Prostate cancer and CAR-T therapy: a systematic review.
Synthesis in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Novel PSCA-Targeting Adapter Molecules for Late-Stage RevCAR-T Cell Therapy in Prostate Cancer.International journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
importanceProstate cancer (PCa) remains a leading cause of cancer-related mortality in men globally, with castration-resistant prostate cancer (CRPC) representing a particularly challenging stage of disease. Despite therapeutic advances, including androgen receptor inhibitors (ARPIs), taxane-based chemotherapy, and radiopharmaceuticals, durable responses in metastatic CRPC (mCRPC) are limited.
objectiveImmunotherapy, especially chimeric antigen receptor (CAR) T cell therapy, has revolutionized hematologic malignancies, yet its application in solid tumors like prostate cancer remains under investigation. We conducted a systematic review in accordance with PRISMA guidelines to evaluate all published and registered clinical trials (2014–2024) involving CAR-T therapy in prostate cancer. EVIDENCE REVIEW: Databases searched included PubMed, ClinicalTrials.gov, and Cochrane. Studies were screened using stringent inclusion/exclusion criteria and analyzed for trial phase, antigen targets, dosing, safety (cytokine release syndrome [CRS], neurotoxicity, dose-limiting toxicities [DLTs]), and early efficacy outcomes. Data extraction was performed independently by two reviewers with AI-assisted adjudication. Out of 32,565 records, 27 trials met inclusion, of which 8 had published outcomes.
findingsEight early-phase trials investigated CAR-T therapies targeting PSMA, PSCA, and other tumor-associated antigens (e.g., CD70, GD2, TGFβDN). PSMA-directed CAR-T trials showed variable safety and preliminary efficacy, with some reporting PSA reductions > 50% and radiographic partial responses. CRS (Grade 1–2) occurred in up to 100% of patients, with isolated cases of neurotoxicity and fatal adverse events in higher-dose cohorts. Trials employing armored CARs (e.g., TGFβDN, iCasp9 switches) demonstrated improved persistence and early anti-tumor activity. The use of dual-target CARs and gene-editing strategies (e.g., piggyBac transposons, PD-1 knockouts) reflect the field’s evolving precision. CONCLUSIONS AND RELEVANCE: CAR-T therapy in prostate cancer, particularly mCRPC, is a promising yet nascent field marked by heterogeneous safety profiles and early signs of efficacy. PSMA remains the most validated target, though antigen escape and tumor microenvironment barriers continue to limit success. Innovative constructs and combinatorial strategies may enhance clinical outcomes. Continued trial development and refinement are critical to unlocking CAR-T’s potential in solid tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.