ArticleBMC psychiatry2026
Peripheral immune cell markers as predictors of electroconvulsive treatment response.
Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResearch indicates that higher levels of inflammation in patients with depression could be associated with a better response to electroconvulsive therapy (ECT). However, studies on the usefulness of immune markers as a potential biomarker for ECT response are scarce.
aimThis study sought to investigate whether peripheral immune cell markers are associated with ECT response in patients with depression.
methodTwenty-seven patients who received ECT treatment with a diagnosis of major depression in the Karadeniz Technical University psychiatry inpatient clinic were evaluated retrospectively. Baseline hemogram parameters of the patients, including neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), and mean platelet volume (MPV) and C-reactive protein (CRP) levels, were determined. The relation of these markers with clinical characteristics, pre- and post-treatment Montgomery-Asberg Depression Rating Scale (MADRS) scores, and treatment response was evaluated.
resultsBaseline serum MPV levels were significantly higher in responders than non-responders to ECT (p = 0.002). Higher baseline MPV levels were significantly correlated with a higher decline in MADRS scores during treatment (r = 0.421, p = 0.029) and lower end-of-treatment MADRS scores (r = -0.489, p = 0.010). In multivariate regression analysis, baseline MPV levels were found to be a significant factor predicting treatment response independent of age, sex, and baseline MADRS scores. At ROC analyses, the optimum cut-off values for prediction of treatment response to ECT were 9.8 for MPV (sensitivity of 72.2%, specificity of 88.9%, p = 0.003).
conclusionMPV could be a potential biomarker for ECT response in patients with depression. Further prospective studies are now needed to verify these findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.