ArticleBMC plant biology2026
Comparative transcriptome analysis identifies key players associated with downy mildew resistance in foxtail millet variety JG21 and its resistant mutant rdm12.
Article in BMC plant biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Modern genomic and omics-based technologies for millet breeding and genetic improvement.Frontiers in plant science · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
backgroundFoxtail millet downy mildew, caused by the obligate parasite Sclerospora graminicola, is a highly devastating disease for foxtail millet. S. graminicola infection often damages buds, leaves, and spikes, significantly compromising its quality and yield. However, resistant varieties can effectively reduce susceptibility to pathogen attacks.
resultsIn this study, we investigated Jingu21 (JG21) and the resistant mutant rdm12, which was generated by ethyl methanesulfonate (EMS) mutagenesis. Phenotypic observations showed that rdm12 did not differ significantly from JG21 in agronomic and quality traits. Notably, rdm12 exhibited enhanced disease resistance, along with increased activities of defense enzymes and higher levels of osmoregulatory substances. Transcriptome analysis of rdm12 mutants and JG21 revealed that differentially expressed genes (DEGs) were mainly enriched in pathways such as plant-pathogen interaction, MAPK signaling, diterpenoid biosynthesis, and glutathione metabolism. The differential expression of several key genes—including receptor protein kinase genes, WRKY transcription factors, pathogenesis-related (PR) proteins, calmodulin, glutathione S-transferase—contributed to improved downy mildew resistance in the mutants. In particular, WRKY transcription factor 53 (encoded by Seita.3G139400), pathogenesis-related protein PRMS (encoded by Seita.3G175100), and G-type lectin S-receptor-like serine/threonine protein kinase (encoded by Seita.7G095600) played an essential role in resistance during S. graminicola infection.
conclusionsThis study identifies key genes and important products involved in resistance, along with their associated metabolic pathways, thereby elucidating the resistance mechanism of foxtail millet against S. graminicola. These findings provide a theoretical foundation for resistance screening in foxtail millet.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.