ArticleNature neuroscience2026
Circuit response to neuromodulation characterized with simultaneous deep brain stimulation and precision neuroimaging in humans.
Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- DBS: from neuromodulation to neuroremodelling.Nature neuroscience · 2026Article
- Entrainment of cortical gamma oscillations predicts improved bradykinesia and dyskinesia in Parkinson's disease.medRxiv : the preprint server for health sciences · 2026Article
- Monosynaptic connections link functionally similar regions in human cortex.bioRxiv : the preprint server for biology · 2026Article
- Parallel processing chains span cytoarchitectures to organize association cortex.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
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Authors and funding
21 authors.
Funding
Abstract
Deep brain stimulation (DBS) is an effective treatment for Parkinson's disease (PD) but its neural mechanisms remain poorly understood. A mechanistic understanding requires precise characterization of functional responses to various stimulation conditions within the same individual. Here we use 3-T magnetic resonance imaging (MRI)-compatible DBS and precision imaging to collect extensive data from 14 patients with PD who received DBS. Across five timepoints spanning 1 year, each patient underwent 11.7 hours of functional MRI (fMRI) under seven stimulation conditions (30-172 min per session), 2.2 hours of structural MRI (26 min per session), 1.3 hours of diffusion-weighted MRI (16 min per session) and neurological assessments. Imaging data were also collected from 27 healthy participants. DBS normalizes connectivity in the somatocognitive action network and evokes differential responses in two distinct neurocircuits: the primary motor and globus pallidus circuits. Target cortical functional connectivity predicts clinical outcomes. This densely sampled dataset provides reliable, individually specific functional measures and is shared with the community to accelerate research into DBS mechanisms and improve personalized treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.