Evidence map›Paper›PMID 41826710›Full record

ArticleNature aging2026

Longitudinal changes in epigenetic clocks predict survival in the InCHIANTI cohort.

Pei-Lun Kuo, Ann Zenobia Moore, Toshiko Tanaka, Daniel W Belsky, Ake Tzu-Hui Lu, Steve Horvath, Stefania Bandinelli, Luigi Ferrucci

Abstract read
In one paragraph

Article in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. A generalized approach for estimating the Pace of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article
  3. Review
  4. Embracing non-linearity in human ageing.Nature reviews. Genetics · 2026
    Review
  5. Epigenetic Clock Trajectories and Brain Health in Midlife.medRxiv : the preprint server for health sciences · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. The Epigenetic Horizon: New Molecular Perspectives.International journal of molecular sciences · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Quantification of Epigenetic Aging in Public Health.Annual review of public health · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pei-Lun Kuo *National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Ann Zenobia Moore *National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Toshiko TanakaNational Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Daniel W BelskyRobert N Butler Columbia Aging Center and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0001-5463-2212
Ake Tzu-Hui LuAltos Labs, San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-2866-7961
Steve HorvathAltos Labs, San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-4110-3589
Stefania BandinelliGeriatric Unit, Local Health Unit Tuscany Centre, Firenze, Tuscany, Italy.
Luigi FerrucciNational Institute on Aging, National Institutes of Health, Baltimore, MD, USA. ferruccilu@grc.nia.nih.gov.ORCID http://orcid.org/0000-0002-6273-1613

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic clocks derived from DNA methylation patterns are among the most promising biomarkers of biological aging

Indexed as

AgingDNA MethylationEpigenesis, GeneticLongevityAgedFemaleHumansLongitudinal StudiesMaleMiddle Aged

Identifiers

PMID41826710
PMCPMC13004684

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.