Evidence map›Paper›PMID 41826699›Full record

ArticleNature cell biology2026

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance.

Vera Skafar, Izadora de Souza, Biplab Ghosh, Ancely Ferreira Dos Santos, Florencio Porto Freitas, Zhiyi Chen, Shibo Sun, Merce Donate Castillo, Palina Nepachalovich, Lars Seufert and 23 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Vera SkafarRudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.
Izadora de SouzaRudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.
Biplab GhoshEuropean Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Ancely Ferreira Dos SantosRudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0003-4985-6187
Florencio Porto FreitasRudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-0369-4488
Zhiyi ChenRudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.
Shibo SunRudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-3019-1413
Merce Donate CastilloRudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0009-0004-2677-5506
Palina NepachalovichCenter of Membrane Biochemistry and Lipid Research, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany.
Lars SeufertDepartment of Biotechnology, Institute for Technical Microbiology, Hochschule Mannheim, Mannheim, Germany.ORCID http://orcid.org/0009-0009-9268-4377
Sebastian BotheRudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.
Juliane TschuckResearch Unit Signaling and Translation, Helmholtz Zentrum München, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-3144-6027
Apoorva MathurInstitute of Chemistry, Technische Universität Berlin, Berlin, Germany.ORCID http://orcid.org/0009-0007-0209-8362
Ariane Nunes-AlvesInstitute of Chemistry, Technische Universität Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-5488-4732
Jannik BuhrHeidelberg Institute for Theoretical Studies, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-9350-2629
Camilo Aponte-SantamaríaHeidelberg Institute for Theoretical Studies, Heidelberg, Germany.
Werner SchmitzDepartment of Biochemistry and Molecular Biology, Theodor Boveri Institute, Biocenter, University of Würzburg, Würzburg, Germany.
Matthias MackDepartment of Biotechnology, Institute for Technical Microbiology, Hochschule Mannheim, Mannheim, Germany.ORCID http://orcid.org/0000-0002-7753-2422
Martin EilersDepartment of Biochemistry and Molecular Biology, Theodor Boveri Institute, Biocenter, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-0376-6533
Ralf BargouComprehensive Cancer Center Mainfranken, University Hospital Würzburg, Würzburg, Germany.
Milena ChaufanDepartment of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0009-0001-3360-6071
Mayher KaurDepartment of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Mario PalmaDepartment of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0009-0007-9456-2096
Jessalyn M UbellackerDepartment of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7855-9125
Ulrich EllingInstitute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna, Austria.ORCID http://orcid.org/0000-0002-4514-2809
Hellmut G AugustinEuropean Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Kamyar HadianResearch Unit Signaling and Translation, Helmholtz Zentrum München, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-8727-2575
Svenja MeierjohannDepartment of Pathology, University of Würzburg, Würzburg, Germany.
Bettina PronethInstitute of Metabolism and Cell Death, Helmholtz Zentrum München (HMGU), Neuherberg, Germany.ORCID http://orcid.org/0000-0002-4119-9437
Marcus ConradInstitute of Metabolism and Cell Death, Helmholtz Zentrum München (HMGU), Neuherberg, Germany.ORCID http://orcid.org/0000-0003-1140-5612
Maria FedorovaCenter of Membrane Biochemistry and Lipid Research, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0002-4692-3885
Hamed AlborziniaHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.
José Pedro Friedmann AngeliRudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany. pedro.angeli@uni-wuerzburg.de.ORCID http://orcid.org/0000-0001-7706-1379

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. More recently, ferroptosis suppressor protein 1 (FSP1) was identified as a critical ferroptosis inhibitor, acting via the regeneration of membrane-embedded antioxidants. Yet, regulators of FSP1 are largely uncharacterized, and their identification is essential for understanding the mechanisms buffering phospholipid peroxidation and ferroptosis. Here we report a focused CRISPR-Cas9 screen to uncover factors influencing FSP1 function, identifying riboflavin (vitamin B

Indexed as

FerroptosisRiboflavinS100 Calcium-Binding Protein A4AnimalsAntioxidantsCell Line, TumorCRISPR-Cas SystemsHumansLipid PeroxidationOxidative StressAntioxidantsRiboflavinS100 Calcium-Binding Protein A4

Identifiers

PMID41826699
PMCPMC13086581

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.