ArticleNature microbiology2026
Plasmids promote antimicrobial resistance through insertion sequence-mediated gene inactivation.
Article in Nature microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- The shared evolutionary capacities of plasmids and extrachromosomal DNA.Nature reviews. Genetics · 2026Review
- Cobalt and nickel ion synergy promotes gene amplification and stable metal resistance inApplied and environmental microbiology · 2026Article
- HERA: a web server for host element reference-based aligner.Nucleic acids research · 2026Article
- In Silico Genomic Analysis of Antibiotic Resistance Genes Carried by Mobile Genetic Elements inInternational journal of molecular sciences · 2026Article
- Phylogenetic Relationships and Structural Conservation ofInternational journal of molecular sciences · 2026Article
- Mobile Genetic Elements as Central Drivers of Antimicrobial Resistance: Molecular Mechanisms, Evolutionary Ecology, One Health Implications and Control Strategies.Antibiotics (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Plasmids are mobile genetic elements that can rapidly spread across bacterial populations, promoting the dissemination of antimicrobial resistance (AMR) genes in bacteria. They are enriched in insertion sequences (IS), which are small transposable elements able to translocate between genetic locations. Here we combined experimental, bioinformatic and computational approaches to investigate the role of plasmids promoting AMR through IS-mediated gene inactivation. We find that plasmid pOXA-48, which encodes two IS1 elements, increases the rate of resistance acquisition to multiple antibiotics in clinical strains of Klebsiella pneumoniae through IS1-mediated gene disruption. Screening of genome databases confirmed that the inactivation of genes through plasmid-encoded IS elements is an extended mechanism of AMR evolution. Both our experiments and computational model revealed that conjugative plasmids can promote this route of AMR acquisition while invading complex bacterial communities. Overall, we show that conjugative plasmids contribute to AMR not only through the dissemination of resistance genes, but also through IS-mediated gene inactivation.
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Registered trials
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