Article in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
16 authors.
Liz M Garcia-Peterson *Molecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.ORCID 0009-0005-4402-4981
Alicia S Wellman *Molecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.ORCID 0009-0000-2848-2994
Xiaojiang Xu *Integrative Bioinformatics, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.ORCID 0000-0001-5758-6581
Ming Ji *Molecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Caroline DuvalMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Igor ShatsMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Xiaoyue WuMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.ORCID 0009-0000-2080-6843
Thomas A RandallIntegrative Bioinformatics, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Hamed BostanIntegrative Bioinformatics, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.ORCID 0000-0003-4102-807X
David CunefareComparative and Molecular Pathogenesis Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Charan K GantaComparative and Molecular Pathogenesis Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Maria SifreMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.ORCID 0009-0004-6675-8102
Xin XuEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.ORCID 0000-0003-2294-0047
Richard S BlumbergDepartment of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Jian-Liang LiIntegrative Bioinformatics, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.ORCID 0000-0002-6487-081X
Xiaoling LiMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA. lix3@niehs.nih.gov.ORCID 0000-0001-5920-7784
Funding
Sirtuins and nuclear receptors in aging and age-associated diseasesZ01ES102205 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LI, XIAOLING · 2007 to 2008
$1.6M
HHS | National Institutes of Health (NIH) DK088199HHS | NIH | National Institute of Environmental Health Sciences (DEHS) Z01 ES102205HHS | NIH | National Institute of General Medical Sciences (NIGMS) 1FI2GM143339-01
6 · The paper itself
Abstract
Paneth cells, intestine-originated innate immune-like cells, are important for maintenance of the intestinal stem cell niche, gut microbiota, and gastrointestinal barrier. Dysfunctional Paneth cells under pathological conditions are a site of origin for intestinal inflammation. However, mechanisms underlying stress-induced Paneth cell dysregulation remain unclear. Here, we report that SIRT1, the most conserved mammalian NAD
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Paneth cell SIRT1 deficiency increases intestinal stress resistance by modulating the gut microbiota. · full record | OpenQuestion