Evidence map›Paper›PMID 41826546›Full record

ReviewCurrent cardiology reports2026

Global Burden of Cardiovascular Disease: What Should Be Expected in the Next 25 Years?

Unaiza Naeem, Salil Deo, Amirhossein Sahebkar, Sana Sheikh, Adeel Khoja, Elizabeth M Vaughan, Ali Bin Abdul Jabbar, Dinesh K Kalra, Leandro Slipczuk, Salim Shahbuddin Virani

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current cardiology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Unaiza NaeemOffice of the Vice Provost, Aga Khan University, Karachi, Pakistan.
Salil DeoLouis Stokes Cleveland VA Medical Center, Cleveland, USA.
Amirhossein SahebkarBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Sana SheikhDepartment of Medicine & Health Data Science Centre, Aga Khan University, Karachi, Pakistan.
Adeel KhojaDepartment of Medicine, The Aga Khan University, Karachi, 74800, Pakistan.
Elizabeth M VaughanDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Ali Bin Abdul JabbarDepartment of Medicine, Division of Internal Medicine, Creighton University School of Medicine, Omaha, NE, 68124, USA.
Dinesh K KalraDivision of Cardiology, University of Louisville, Louisville, KY, USA.
Leandro SlipczukMontefiore Health System, New York, NY, USA.
Salim Shahbuddin ViraniOffice of the Vice Provost, Aga Khan University, Karachi, Pakistan. salim.virani@aku.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThe aim of this review is to evaluate the evolving burden of cardiovascular disease (CVD) between 2025 and 2050. RECENT

findingsBetween 1990-2023, CVD deaths increased from 13.1 million to 19.2 million, with prevalence rising from 311 to 626 million cases. Most CVD burden is attributable to modifiable risk factors, led by high systolic blood pressure (SBP). By 2050, CVD mortality will reach 35.6 million deaths annually, while prevalence will be at 1.14 billion cases globally. Metabolic, environmental and behavioral determinants will be key drivers, varying across regions according to sociodemographic index. Age-standardized mortality rates will decline, but absolute numbers of people living with CVD will rise due to population growth, aging, and possibly also improved access to care, especially in low-middle income countries. Prevention strategies, early detection and treatment, and better implementation of what is already known are necessary to address this burden.

Indexed as

Cardiovascular DiseasesGlobal HealthGlobal Burden of DiseaseHeart Disease Risk FactorsHumansPrevalenceRisk FactorsCardiovascular Disease BurdenMetabolic risk factorsPopulation AgingPopulation GrowthPrimary preventionRisk Factors

Identifiers

PMID41826546

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.