Observational studyAnnals of surgical oncology2026
Targeted Preoperative Nutritional Support within an Enhanced Recovery After Surgery Program for Malnourished Colorectal Cancer Patients: Postoperative Outcomes Comparable to Well-Nourished Patients in a Prospective Single-Center Cohort.
Observational study in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Comparable Does Not Mean Equivalent: Causal Inference Gaps in Nutritional Prehabilitation for Malnourished Colorectal Cancer Patients.Annals of surgical oncology · 2026Article
- ASO Author Reflections: Can Targeted Nutrition Level the Playing Field? Reflections on Preoperative Support for Malnourished Colorectal Cancer Patients in ERAS.Annals of surgical oncology · 2026Article
- Association between preoperative inflammatory biomarkers and postoperative morbidity and mortality in stage I-III colorectal cancer patients: a single-centre prospective study.BMJ connections surgery · 2026Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalnutrition is associated with poor surgical outcomes, but evidence supporting targeted nutritional intervention within multimodal pathways remains limited. We assessed whether preoperative nutritional support, delivered selectively to malnourished colorectal cancer patients within an Enhanced Recovery After Surgery (ERAS) framework, was associated with postoperative outcomes comparable to those of well-nourished patients.
methodsWe conducted a prospective observational cohort study in an ERAS-certified Spanish hospital between January 2020 and December 2021. A total of 187 consecutive adult patients undergoing elective primary colorectal cancer resection were screened for malnutrition by using Malnutrition Universal Screening Tool and Global Leadership Initiative on Malnutrition criteria. Malnourished patients received individualized nutritional counseling and oral nutritional supplements ≥ 7 days preoperatively, per ESPEN guidelines. Primary outcomes were length of stay (LOS) and 30-day postoperative complications. Multivariable logistic and Cox regression models adjusted for age, sex, body mass index, American Society of Anesthesiologists class, and nutritional status.
resultsThe cohort's mean age was 69.3 ± 9.6 years, 62.6% were male, and 42 (22.4%) were diagnosed with malnutrition. No significant differences were observed in complication rates (38.1% vs. 31.7%, P = 0.276) or LOS (median 8 vs. 7 days, P = 0.36) between malnourished and well-nourished groups. In multivariable analysis, malnutrition was not independently associated with postoperative complications (adjusted odds ratio 1.47; 95% confidence interval 0.7-3.07; P = 0.31) or prolonged LOS (adjusted odds ratio 0.77; 95% confidence interval 0.53-1.12; P = 0.17). No 30-day deaths occurred.
conclusionsWithin a structured ERAS program, targeted preoperative nutritional support was associated with postoperative outcomes that were not worse than those of well-nourished peers. These findings support a selective "screen-and-treat" nutritional strategy in routine perioperative care.
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