ArticleAnalytical and bioanalytical chemistry2026
Optimized methods for adsorbable organic halides (AOX) and halogen‑specific speciation for tracking disinfection by-products from source to tap.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Disinfection by-products (DBPs) formed during drinking water treatment pose a significant public health risk due to their ubiquity and documented toxicity, including carcinogenic, genotoxic, and developmental effects. While European regulations currently limit monitoring to trihalomethanes (THMs) and haloacetic acids (HAAs), they overlook highly toxic brominated and iodinated DBPs, which exhibit greater toxicity than their chlorinated counterparts. To address this gap, adsorbable organic halides (AOX) have emerged as a promising bulk parameter, integrating both the total concentration and potential toxicity of halogenated DBPs. Halogen-specific AOX speciation (AOCl, AOBr, AOI) and the distinction between purgeable (POX) and non-purgeable organic halides (NPOX) further refine risk assessments, as these fractions differ in toxicity and exposure pathways. This study optimizes and validates analytical methods for AOX, NPOX, and halogen-specific AOX, focusing on critical parameters-including adsorption efficiency, volatilization, matrix interferences, and ion chromatography conditions-to enhance method robustness. The optimized protocol achieved limits of quantification (LOQs) of 25 µg Cl·L⁻
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