Evidence map›Paper›PMID 41826436›Full record

ReviewNature reviews. Microbiology2026

Human herpesvirus evasion of humoral immunity and implications for vaccine development.

Claire E Otero, Matthew D Slein, Libby Mitchell, Adarsh Ramloul, Philipp Kolb, Margaret E Ackerman, Sallie R Permar

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Claire E OteroDepartment of Pediatrics, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-7127-2327
Matthew D SleinThayer School of Engineering, Dartmouth College, Hanover, NH, USA.ORCID http://orcid.org/0000-0001-8288-787X
Libby MitchellDepartment of Pediatrics, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0009-0003-1189-1873
Adarsh RamloulDepartment of Pediatrics, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0009-0005-3057-2362
Philipp KolbInstitute of Virology, University Medical Center, Freiburg, Germany.ORCID http://orcid.org/0000-0001-7935-217X
Margaret E AckermanThayer School of Engineering, Dartmouth College, Hanover, NH, USA.ORCID http://orcid.org/0000-0002-4253-3476
Sallie R PermarDepartment of Pediatrics, Weill Cornell Medicine, New York, NY, USA. sap4017@med.cornell.edu.ORCID http://orcid.org/0000-0003-1438-4554

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herpesviruses are highly species-specific, having co-evolved with their respective hosts over millennia. This evolutionary relationship has led to the development of highly specialized immune evasion strategies, enabling these viruses to establish lifelong infections. Periods of immunosuppression can lead to severe disease, such as graft rejection, cancer, neurodegenerative disease and autoimmune diseases, which have been linked to herpesvirus infections. Consequently, developing strategies to prevent herpesvirus-associated diseases is a critical public health priority. However, varicella zoster virus (VZV) remains the only human herpesvirus for which licensed vaccines are available. This Review explores the mechanisms of humoral immune evasion by herpesviruses and their implications for advancing immunization and treatment strategies for chronic neurological, oncological and transplant-associated diseases caused by these common viral pathogens.

Indexed as

HerpesviridaeHerpesviridae InfectionsHerpesvirus 3, HumanHerpesvirus VaccinesImmune EvasionImmunity, HumoralVaccine DevelopmentAnimalsHumansHerpesvirus Vaccines

Identifiers

PMID41826436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.