Evidence map›Paper›PMID 41826412›Full record

ArticleNpj viruses2026

Site-1 protease mediated GPC processing is required for persistence of LCMV Clone 13.

Ruifeng Zhou, Haydar Witwit, Tingting Ai, Maheeka Bimal, Rachel Y Sattler, Kristi L Marquardt, Beatrice Cubitt, Arthur S Kim, John R Teijaro, Juan Carlos de la Torre

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Npj viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruifeng ZhouDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Haydar WitwitDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Tingting AiDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Maheeka BimalDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Rachel Y SattlerDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Kristi L MarquardtDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Beatrice CubittDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Arthur S KimDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
John R TeijaroDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. teijaro@scripps.edu.
Juan Carlos de la TorreDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. juanct@scripps.edu.

Funding

The role of IL-27 in sustaining the exhausted CD8 T cell response to persistent infection and cancer.R01AI164744 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI TEIJARO, JOHN ROSS · 2021 to 2025
$2.7M
The Training Core for The San Diego Regional Network Award for Kidney, Urologic, and Hematologic Research TrainingTL1DK143272 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Dena Evette Rifkin · 2024 to 2026
$1.2M
National Institute of Allergy and Infectious Diseases RO1 AI125626NIAID NIH HHS R01 AI164744NIDDK NIH HHS TL1 DK143272
6 · The paper itself

Abstract

Most enveloped viruses rely on furin for maturation of their surface glycoprotein. In contrast, mammarenaviruses process their glycoprotein precursor (GPC) using host site-1 protease (S1P), yet the biological implications of this unique reliance on S1P remain unclear. Here, we characterized a furin-dependent recombinant form (rCl13-RRRR) of the persistent clone 13 variant of LCMV (rCl13). Although rCl13-RRRR exhibited fitness comparable to rCl13 in cultured cells, it was highly attenuated in vivo and failed to establish persistence in immunocompetent mice. Clearance of rCl13-RRRR required interferon and CD8

Identifiers

PMID41826412
PMCPMC12987983

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.