ArticleScientific reports2026
Deciphering the groove-binding mode of dolutegravir with salmon sperm DNA through spectroscopic and molecular modelling approaches.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Understanding how small molecules interact with DNA opens new avenues for designing smarter, more selective therapies. These studies not only shed light on off-target effects that could cause side effects or influence treatment outcomes but also help predict a drug's genotoxic potential, aiding long-term safety assessments. Dolutegravir (DGV) serves as a second-generation integrase inhibitor used as a first-line antiretroviral therapy for managing human immunodeficiency virus (HIV) infection. Recent studies have positioned DGV as a prospective lead compound for repositioning antiretrovirals as cancer treatments. Building on this perspective, the introduced protocol presents a detailed approach to exploring DGV's genomic interactions using salmon sperm DNA (SS-DNA) as a reliable genomic surrogate, employing various biophysical methods, including spectroscopic analysis, viscosity profiling, ionic strength experiments, and molecular docking. UV-Visible results indicate that DGV binds to DNA grooves with a binding constant of 10
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