SynthesisScientific reports2026
Association between TNF-α polymorphisms and responsiveness to TNF-α blockers in ankylosing spondylitis and psoriatic arthritis: a meta-analysis.
Synthesis in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
To investigate the association between tumor necrosis factor-alpha (TNF-α) polymorphisms and the responsiveness to anti-TNF-α therapy in patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA). A comprehensive literature search of the PubMed/Medline, Embase, and Web of Science databases was performed to identify relevant published studies. Meta-analysis was performed to assess the relationship between specific TNF-α polymorphisms (-308 A/G, + 489 A/G, -238 A/G, -857 C/T, or -1031 C/T) and the responsiveness of patients with AS or PsA to anti-TNF-α therapy. The study was registered in PROSPERO (CRD42023472655). The analysis incorporated data from 11 comparison studies within 9 articles, involving 611 patients (453 responders and 158 non-responders). Meta-analysis revealed a significant association between the TNF-α -308 G allele and a positive response to TNF-α blockers (odds ratio [OR] 4.221 [95% confidence interval (CI) 1.691–10.54]; p = 0.002). Stratification according to ethnicity demonstrated this association in both the European and Asian populations. Disease-specific meta-analyses indicated an association between the TNF-α -308 G allele and a favorable response to TNF-α blockers in those with AS and PsA. However, the TNF-α + 489 GG genotype did not exhibit a consistent association with the response in PsA, although a single study suggested an association in AS. Furthermore, TNF-α -857 C and − 238 G alleles were associated with a positive response to TNF-α blockers in PsA. No association was found between the TNF-α -1037 TT genotype and response in PsA. Results of this meta-analysis provide evidence supporting a significant association between the TNF-α -308 G allele and an increased responsiveness to TNF-α blockers in AS and PsA. It also suggests that TNF-α -857 C and − 238 G alleles may influence TNF-α blocker responsiveness in PsA.
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