Evidence map›Paper›PMID 41826316›Full record

ArticleNature communications2026

A conserved, immune-regulated peritrophin promotes Vibrio cholerae colonization of the arthropod intestine.

Daniela Barraza, Tânia F Paulo, Lauren Findley, Saiyu Hang, Paula I Watnick

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniela Barraza *Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6719-6197
Tânia F Paulo *Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8815-2636
Lauren FindleyDivision of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Saiyu HangDivision of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Paula I WatnickDivision of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA. paula.watnick@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-9173-8662

Funding

Vibrio cholerae quorum sensing as an intestinal symbiosis factor in a model arthropod hostR01AI162701 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PAULA I WATNICK · 2021 to 2026
$4.3M
Control of intestinal innate immunity by the commensal microbiota in a model hostR01AI158247 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI WATNICK, PAULA I · 2021 to 2025
$3.5M
NIAID NIH HHS R01 AI158247NIAID NIH HHS R01 AI162701U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) R01AI158247U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) R01AI162701
6 · The paper itself

Abstract

Vibrio cholerae is a human diarrheal pathogen and an estuarine organism that associates with both terrestrial and aquatic arthropods. Using the model terrestrial arthropod Drosophila melanogaster, we previously showed that V. cholerae adheres to the arthropod intestine and activates the enteroendocrine cell innate immune response to augment expression of the enteroendocrine peptide tachykinin (Tk). Here we show that enteroendocrine innate immune signaling and Tk promote V. cholerae colonization of the arthropod intestine. To investigate this, we measure the impact of Tk

Indexed as

Drosophila melanogasterDrosophila ProteinsIntestinesVibrio choleraeAnimalsChitinEnteroendocrine CellsImmunity, InnateIntestinal MucosaChitinDrosophila Proteins

Identifiers

PMID41826316
PMCPMC13128822

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.