ArticleJournal of medicinal chemistry2026
Development and Evaluation of Benzofuran Oxoacetic Acid Compounds as EPAC1 Activators.
Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Exchange protein directly activated by cAMP 1 (EPAC1) modulates Rap signaling and fibrosis. We report benzofuran oxoacetic acids as non-nucleotide EPAC1 agonists. Convergent synthesis delivered C2-diversified analogues (overall yields ≈ 3-7%). Fluorescent competition at isolated CNBDs mapped isoform engagement: several analogues favored EPAC1 (e.g.,
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