SynthesisBMJ open gastroenterology2026
Advanced imaging (narrow band and acetic acid chromoendoscopy) and guided biopsies in surveillance of Barrett's oesophagus: a systematic review.
Synthesis in BMJ open gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo systematically synthesise the evidence behind the use of narrow band imaging (NBI) and acetic acid chromoendoscopy (AAC) in Barrett's oesophagus (BO) surveillance.
designThe exploration phase followed the conceptual frameworks of Arksey and O'Malley and Levac DATA SOURCES: PubMed, Medline, Scopus, Web of Science, Embase, CINHAL, Gray literature (GreyNet and OpenGrey) and reference reading. ELIGIBILITY CRITERIA: Peer-reviewed full publications on interventional studies and cohort studies reporting effectiveness of NBI or AAC used for BO surveillance were included. Database searches were performed without restrictions on date of publication, up to the search period (December 2024-January 2025). Other observational studies, abstracts and non-English publications were excluded. DATA EXTRACTION AND SYNTHESIS: Data extraction and synthesis was performed by two reviewers using Covidence. The data were synthesised narratively and evaluated for quality of evidence.
resultsInitial search produced 974 articles. After excluding duplicates (389), ineligible articles (526) and abstract-only publications (15), 44 articles were selected for inclusion. Results indicated that NBI-targeted biopsies are more effective in overall dysplasia detection than white light endoscopy (WLE). While NBI and AAC are both effective in BO diagnosis with a smaller number of biopsies, AAC demonstrated a higher sensitivity for neoplasia detection than WLE. However, neither NBI-guided nor AAC-guided biopsy was able to replace Seattle protocol.
conclusionNBI provides higher dysplasia detection and AAC has a higher sensitivity, but neither can safely replace Seattle protocol biopsies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.