Evidence map›Paper›PMID 41825843›Full record

ArticleAmerican journal of ophthalmology2026

Optic Disc Structural Progression in Glaucoma Suspect Eyes With Microvascular Dropout.

Ghazaleh Soltani, Takashi Nishida, Sasan Moghimi, Eleonora Micheletti, Seyedehmelika Hashemi, Amelia de Oliveira Pereira, Robert N Weinreb

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ghazaleh SoltaniFrom the Hamilton Glaucoma Center (G.S., T.N., S.M., S.H., A.d.O.P., and R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
Takashi NishidaFrom the Hamilton Glaucoma Center (G.S., T.N., S.M., S.H., A.d.O.P., and R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
Sasan MoghimiFrom the Hamilton Glaucoma Center (G.S., T.N., S.M., S.H., A.d.O.P., and R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
Eleonora MichelettiMoorfields Eye Hospital (E.M.), London, UK.
Seyedehmelika HashemiFrom the Hamilton Glaucoma Center (G.S., T.N., S.M., S.H., A.d.O.P., and R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
Amelia de Oliveira PereiraFrom the Hamilton Glaucoma Center (G.S., T.N., S.M., S.H., A.d.O.P., and R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
Robert N WeinrebFrom the Hamilton Glaucoma Center (G.S., T.N., S.M., S.H., A.d.O.P., and R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA. Electronic address: rweinreb@ucsd.edu.

Funding

Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2012 to 2026
$10.3M
Diagnostic Innovations in Glaucoma:Structural AssessmentR01EY011008 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 1995 to 2015
$8.7M
Diagnostic Innovations in Glaucoma Study (DIGS): High Myopia and Advanced DiseaseR01EY027510 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2017 to 2026
$5.3M
Diagnosis and Monitoring of Glaucoma with Optical Coherence Tomography AngiographyR01EY029058 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WEINREB, ROBERT N · 2018 to 2024
$4.2M
African Descent and Glaucoma Evaluation (ADAGES) II: Glaucoma ProgressionR01EY019869 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2010 to 2014
$2.8M
African Descent and Glaucoma Evaluation (ADAGES) IV: Alterations of the lamina cribrosa in progressionR01EY026574 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FAZIO, MASSIMO ANTONIO, GIRKIN, CHRISTOPHER ANTHONY · 2017 to 2020
$2.6M
Monitoring of Glaucoma Patients in Advanced DiseaseR01EY034148 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sasan Moghimi Araghi · 2022 to 2026
$2.5M
NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY011008NEI NIH HHS R01 EY019869NEI NIH HHS R01 EY026574NEI NIH HHS R01 EY027510NEI NIH HHS R01 EY029058NEI NIH HHS R01 EY034148
6 · The paper itself

Abstract

purposeTo investigate the relationship of structural progression, β-zone parapapillary atrophy (PPA) progression, and microvascular dropout (MvD) in glaucoma suspect eyes.

designRetrospective cohort study.

methodsEyes were included if optic disc photographs were available at least 5 years before optical coherence tomography angiography imaging. During follow-up, structural progression and β-zone PPA progression were recorded. Structural progression was graded using stereophotographs; eyes were classified as progressing if new or enlarged retinal nerve fiber layer defects or neuroretinal rim thinning were detected. β-zone PPA was quantified (area, radial width, angular extent), with progression defined as a ≥20% increase in any parameter. The presence of MvD at the last visit was evaluated using en-face choroidal vessel density maps. Multivariable logistic regression was used to assess the association between MvD and structural progression, adjusting for covariates and β-zone PPA progression. Margins analysis was performed to estimate predicted probabilities of structural progression by MvD status and β-zone PPA progression.

resultsA total of 180 eyes from 134 glaucoma suspect patients were included, of which 58 eyes (32.2%) had MvD. The mean follow-up duration for fundus photographs was 19.0 (95% CI, 17.9-20.1) years. The presence of MvD and also β-zone PPA progression were significantly associated with structural progression (15.8 [95% CI, 5.6-44.6], P < .001; 3.8 [95% CI, 1.2-11.7], P = .022, respectively). Margin plots indicated that eyes exhibiting both MvD and β-zone PPA progression had the highest estimated probability of structural progression (0.75).

conclusionsIn glaucoma suspect eyes, the presence of both MvD and β-zone PPA progression were independently associated with structural optic disc progression. These structural changes were observed in glaucoma suspect eyes that remained clinically stable and did not convert to perimetric glaucoma during the period of observation in this study. Recognition of these changes may enhance more timely management to prevent glaucomatous vision loss.

Indexed as

Glaucoma, Open-AngleOcular HypertensionOptic AtrophyOptic DiskRetinal VesselsAgedDisease ProgressionFemaleFluorescein AngiographyFollow-Up StudiesHumansIntraocular PressureMaleMiddle AgedNerve FibersRetinal Ganglion Cells

Identifiers

PMID41825843
PMCPMC13436852

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.