ArticleAnalytical biochemistry2026
Coupled-enzyme assay for MTAP activity in biological samples.
Article in Analytical biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
5'-Methylthioadenosine phosphorylase (MTAP) catalyzes the reversible phosphorolysis of 5'-methylthioadenosine (MTA), a product of polyamine synthesis. The resulting products, adenine and 5-methylthio-α-d-ribose 1-phosphate (MTR-1-P), are salvaged to the adenylate and methionine pathways. Homozygous deletion of MTAP occurs in approximately 15% of all human cancers due to its chromosomal proximity to the CDKN2A/B locus. Loss of MTAP creates a metabolic vulnerability to PRMT5 and MAT2A inhibition, resulting in a synthetic lethal interaction. Consequently, MTAP has emerged as a target for enzymatic inhibition to enable synthetic lethal strategies in the 85% of cancers that are MTAP
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.