Evidence map›Paper›PMID 41825221›Full record

ReviewEBioMedicine2026

Integrating explainable AI and One Health: a new frontier in combating infectious diseases.

Yanni Cao, Emma Lancaster, Jiyoung Lee, Jianyong Wu

Abstract readReview
In one paragraph

Review in EBioMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yanni CaoDivision of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, 43210, USA.
Emma LancasterDivision of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, 43210, USA.
Jiyoung LeeDivision of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, 43210, USA; Infectious Diseases Institute, The Ohio State University, Columbus, OH, 43210, USA; Department of Food Science & Technology, The Ohio State University, Columbus, OH, 43210, USA.
Jianyong WuDivision of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, 43210, USA. Electronic address: wu.6255@osu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infectious diseases (IDs) remain a major threat to global health and societal stability. Because most emerging IDs in humans are zoonotic in origin and shaped by environmental contexts, effective prevention and control call for a One Health approach. Machine learning is widely used for ID modelling and forecasting but often lacks interpretability to explain predictions or guide public health action. Explainable AI (XAI) makes complex models interpretable, enabling attribution of predictions and identification of key outbreak drivers. In this Personal View, we argue that embedding XAI within a One Health framework offers a new organising principle for ID intelligence. We highlight emerging applications in surveillance and forecasting, zoonotic spillover, antimicrobial resistance monitoring and optimisation of resource allocation. We also outline key challenges, including data harmonisation, governance, privacy protection and equitable distribution of risks and benefits. Advancing XAI-enabled One Health systems will require collaboration across sectors and methodological innovation.

Indexed as

Artificial IntelligenceCommunicable DiseasesOne HealthAnimalsData AnalyticsDisease OutbreaksHumansExplainable artificial intelligence (XAI)Infectious diseasesOne HealthPredictive modelling

Identifiers

PMID41825221
PMCPMC12997009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.