ArticleClinics (Sao Paulo, Brazil)2026
Body composition paradox: high muscle mass and adiposity jointly predict incident chronic kidney disease in a Korean cohort.
Article in Clinics (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveDiabetes, hypertension, and obesity are common traditional risk factors for Chronic Kidney Disease (CKD). In this population-based longitudinal study, the authors identified risk factors associated with CKD development.
methodA total of 6,238 Korean adults aged 40- to 69-years without baseline CKD were included. Among them, 4,057 participants with baseline estimated Glomerular Filtration Rate (eGFR) measurements were analyzed. Logistic regression models were used to evaluate significant predictors of CKD.
resultsOver a 10-year follow-up period, CKD developed in 354 subjects (8.7 %). Leptin levels were significantly higher in participants who developed CKD compared to those who did not (8.89 ± 8.00 vs. 6.44 ± 5.52, p < 0.001). After adjusting for confounding factors, logistic regression analysis indicated that participants in the highest quartile of muscle mass were 2.314-times more likely to develop CKD compared to those in the lowest quartile (Odds Ratio [OR = 2.314]; 95 % Confidence Interval [95 % CI: 1.372-3.902]; p = 0.014). In multivariable-adjusted models, the OR for incident CKD when comparing the lowest to the highest quartiles of body fat was 2.166 in men; however, the significance disappeared after adjusting for eGFR. Among women, higher leptin levels and lower adiponectin levels were independently associated with incident CKD (p = 0.003 and p = 0.038, respectively), regardless of traditional CKD risk factors. Furthermore, compared to subjects without CKD, those with metabolic syndrome had an OR (95 % CI) of 5.256 (2.813-9.820) for incident CKD after controlling for confounding factors.
conclusionThese findings suggest that muscle mass and body fat may serve as better predictors of incident CKD.
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