Evidence map›Paper›PMID 41824931›Full record

ArticleChemMedChem2026

Synthesis, Biological Evaluation, and Theoretical Study of Indenoquinolinylphosphine Oxide Derivatives as Topoisomerase 1 Inhibitors and Antiproliferative Agents.

Alba Rodriguez, Elena Formoso, Birgitta R Knudsen, Cinzia Tesauro, Maria Fuertes, Concepcion Alonso

Abstract read
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alba RodriguezDepartment of Organic Chemistry I, Faculty of Pharmacy, University of Basque Country (EHU), Vitoria-Gasteiz, Spain.
Elena FormosoDepartment of Physical Chemistry, Faculty of Pharmacy, University of Basque Country (EHU), Vitoria-Gasteiz, Spain.
Birgitta R KnudsenDepartment of Molecular Biology and Genetics and Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, Denmark.
Cinzia TesauroDepartment of Molecular Biology and Genetics and Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, Denmark.
Maria FuertesDepartment of Organic Chemistry I, Faculty of Pharmacy, University of Basque Country (EHU), Vitoria-Gasteiz, Spain.ORCID https://orcid.org/0000-0002-6959-6266
Concepcion AlonsoDepartment of Organic Chemistry I, Faculty of Pharmacy, University of Basque Country (EHU), Vitoria-Gasteiz, Spain.ORCID https://orcid.org/0000-0003-0866-3493

Funding

Hezkuntza, Hizkuntza Politika Eta KulturaSaila, Eusko Jaurlaritza IT1701-22Ministerio de Ciencia e Innovación PID2021-122558OB-I00
6 · The paper itself

Abstract

The topoisomerase 1 (TOP1) enzymatic inhibition and antiproliferative activity of phosphorated indenoquinoline derivatives were investigated. First, the preparation of new hybrid quinoline and tetrahydroquinoline structures with a phosphine oxide group was performed by a two-step Povarov type [4 + 2]-cycloaddition reaction between the corresponding phosphorated aldimines with indene in the presence of BF

Indexed as

Antineoplastic AgentsDNA Topoisomerases, Type IOxidesPhosphinesQuinolinesTopoisomerase I InhibitorsCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsDNA Topoisomerases, Type IOxidesPhosphinesQuinolinesTOP1 protein, humanTopoisomerase I Inhibitorsantiproliferative agentsenzyme inhibitionindenoquinolinestopoisomerase 1

Identifiers

PMID41824931
PMCPMC12987641

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.