ArticleMedicine2026
Different response to vitamin D supplementation in children with RVOT morphology PVCs vs LV fascicular PVCs.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Outflow tract premature ventricular contractions (PVCs) are typically benign arrhythmias in structurally normal hearts. Vitamin D insufficiency has been shown to cause PVCs in both children and adults. This study examined the impact of vitamin D supplementation in children with an increased burden of PVCs in 2 patient categories with distinct electrocardiogram morphologies: right ventricular outflow tract (RVOT) and left fascicular. We enrolled 46 patients (mean age 10.6 ± 4.1 years, 26% female) showing an increased burden of monomorphic PVCs (mean = 18,925/24 hours) and vitamin D deficiency. We compared 36 patients with RVOT morphology and 10 patients with left ventricular fascicular morphology. In the RVOT morphology group, the mean age was 12.7 ± 2.7 years, comprising 75% males and 25 females, with a PVC burden of 18,343.7 ± 13,836.2/24 hours and a 25-OH vitamin D level of 23.5 ± 9.4 ng/mL. After 2 months of oral vitamin D supplementation, the vitamin D level increased to 41.6 ± 6.3, followed by a considerable reduction in PVC burden to 3628.0 ± 2347.2. This group of children showed 80% reduction in PVC burden. In the left ventricular fascicular morphology group, the mean age was 6.9 ± 5.5 years, comprising 71% males and 29% females, with a PVC burden of 20,535.3 ± 20,867.9, and a vitamin D level of 25.8 ± 7.1 ng/mL. Following 3 months of oral vitamin D supplementation, vitamin D levels increased to 65.8 ± 42.8 ng/mL; however, there was no significant change in PVC burden (19,207.1 ± 22,807.8). Vitamin D supplementation may be effective in reducing PVC burden in children with vitamin D deficiency and RVOT PVCs.
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