Evidence map›Paper›PMID 41824802›Full record

ReviewChemMedChem2026

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry.

Iago C Vogel, Manuel J Verganista, Nuno R Candeias

Abstract readReview
In one paragraph

Review in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Iago C VogelLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal.ORCID https://orcid.org/0009-0006-3966-2265
Manuel J VerganistaLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal.
Nuno R CandeiasLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal.ORCID https://orcid.org/0000-0003-2414-9064

Funding

Fundação para a Ciência e a Tecnologia 2024.04089.BDANAFundação para a Ciência e a Tecnologia PTDC/QUI-QOR/1131/2020Fundação para a Ciência e a Tecnologia UID/50006/2025
6 · The paper itself

Abstract

Quinic acid (QA) is a natural product recognized for its potential in medicinal chemistry. While traditionally studied as a structural moiety of chlorogenic acids, QA and synthetic derivatives thereof are becoming more relevant as independent scaffolds with broad therapeutic relevance. This review highlights the growing body of work on their biological activities, including anti-inflammatory, antibacterial, and anticancer effects, as well as their roles in metabolic and immune modulation. Chemically, QA offers a rich framework for structural modification, enabling the design of diverse molecules with improved properties for drug development. Several derivatives have shown promising results in preclinical models, and new synthetic strategies continue to expand their applicability. By focusing on QA itself, instead of its more commonly studied esters, this review underscores its emerging value as a versatile and underutilized scaffold.

Indexed as

Anti-Bacterial AgentsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsQuinic AcidAnimalsChemistry, PharmaceuticalHumansMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsQuinic Acidantibacterialantitumor agentsantiviral agentscarbacylesquinic acid

Identifiers

PMID41824802
PMCPMC12987601

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.