Evidence map›Paper›PMID 41824792›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A Tac1-Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia.

Liting Sun, Jia-Jia Wang, Xiang-Yu Li, Xin-Yi Lin, Juan Li, Qiu-Tong Yu, Zi-Han Wang, Xue-Ping Gao, Lei Jin, Wei-Ke Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Liting SunDepartment of Anesthesiology, Huadong Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Jia-Jia WangDepartment of Anesthesiology, Huadong Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Xiang-Yu LiDepartment of Anesthesiology, Huadong Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Xin-Yi LinDepartment of Anesthesiology, Huadong Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Juan LiDepartment of Anesthesiology, Huadong Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Qiu-Tong YuDepartment of Anesthesiology, Huadong Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Zi-Han WangDepartment of Anesthesiology, Huadong Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Xue-Ping GaoLingang Laboratory, Shanghai, China.
Lei JinLingang Laboratory, Shanghai, China.
Wei-Ke LiDepartment of Anesthesiology, Huadong Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Tian-Lin ChengDepartment of Anesthesiology, Huadong Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Juan DengDepartment of Anesthesiology, Huadong Hospital, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-7875-1865

Funding

National Natural Science Foundation of China 31825013National Natural Science Foundation of China 82101320National Natural Science Foundation of China 82222020National Science and Technology Innovation 2030 Major Program 2022ZD0207300
6 · The paper itself

Abstract

Trigeminal neuralgia (TN) is widely recognized to be one of the most severe pain disorders, severely affects the life quality of patients. However, the neuronal mechanisms underlying TN pathogenesis remain largely unknown. Here, we identify a periphery-to-brain neural circuit that governs TN development in mice. Tachykinin 1 (Tac1)-expressing parabrachial nucleus (PBN

Indexed as

Brain StemTachykininsTrigeminal NeuralgiaAnimalsDisease Models, AnimalMaleMiceNeuronsParabrachial NucleusTrigeminal GanglionTrigeminal Nucleus, SpinalTachykininscaudal part of spinal trigeminal nucleus (Sp5C)CIONparabrachial nucleus (PBN)Sp5C projection neuronsTac1 genetrigeminal ganglion (TG)trigeminal neuralgia

Identifiers

PMID41824792
PMCPMC13205611

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.