Evidence map›Paper›PMID 41824774›Full record

ArticleeLife2026

Insights into substrate binding and utilization by hyaluronan synthase.

Zachery Stephens, Julia Karasinska, Jochen Zimmer

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Zachery StephensUniversity of Virginia School of Medicine, Charlottesville, United States.ORCID https://orcid.org/0009-0001-0140-5304
Julia KarasinskaUniversity of Virginia School of Medicine, Charlottesville, United States.ORCID https://orcid.org/0009-0008-4298-9159
Jochen ZimmerUniversity of Virginia School of Medicine, Charlottesville, United States.ORCID https://orcid.org/0000-0002-8423-2882

Funding

Synthesis, secretion and assembly of extracellular complex carbohydrates in Gram-negative bacteriaR35GM144130 · NIGMS · UNIVERSITY OF VIRGINIA · PI Jochen Zimmer · 2022 to 2026
$2.5M
NIH HHS R35GM144130
6 · The paper itself

Abstract

Hyaluronan (HA), a heteropolysaccharide of alternating

Indexed as

Hyaluronan SynthasesHyaluronic AcidCryoelectron MicroscopyPhycodnaviridaeProtein BindingSubstrate SpecificityUridine Diphosphate N-AcetylglucosamineHyaluronan SynthasesHyaluronic AcidUridine Diphosphate N-Acetylglucosaminebiochemistryenzyme mechanismextracellular matrixhyaluronanmolecular biophysicsnonepolysaccharidestructural biology

Identifiers

PMID41824774
PMCPMC12987647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.