Evidence map›Paper›PMID 41824628›Full record

ArticleActa haematologica2026

A Complex Case of Anti-e Mimicking Autoantibody Development Leading to Warm Autoimmune Hemolytic Anemia: Case Report.

Ilsa Hale, Kristina L Kunes, Jean Sabile, Jacob Dougherty, Trisha Wong, Michael Heinrich

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta haematologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ilsa HaleDepartment of Internal Medicine, Oregon Health and Science University, Portland, Oregon, USA, halei@ohsu.edu.
Kristina L KunesDepartment of Internal Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Jean SabilePortland VA Health Care System and the Division of Hematology and Oncology, Oregon Health and Science University, Portland, Oregon, USA.
Jacob DoughertyDepartment of Pathology and Laboratory Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Trisha WongDepartment of Pathology and Laboratory Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Michael HeinrichPortland VA Health Care System and the Division of Hematology and Oncology, Oregon Health and Science University, Portland, Oregon, USA.

Funding

National Succinate Dehydrogenase-deficient GIST Translational Research and Clinical Trial ConsortiumU01CA278470 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOHN Walter GLOD, Jason Keith Sicklick · 2024 to 2026
$1.8M
Novel models for functional profiling of germline SDH variants associated with cancerR21CA263400 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI HEINRICH, MICHAEL C · 2021 to 2022
$320k
BLRD VA I01 BX005358NCI NIH HHS R21 CA263400NCI NIH HHS U01 CA278470
6 · The paper itself

Abstract

introductionNewly diagnosed autoimmune hemolytic anemia (AIHA) develops in 1-3 individuals per 100,000 people per year. Warm autoimmune hemolytic anemia (WAIHA) is the most common type of AIHA, accounting for approximately 70-80% of cases. This report outlines a complex presentation of DAT-negative, anti-e-mimicking autoantibody mediated WAIHA following a transient viral infection in an adult male patient with no prior transfusions. CASE PRESENTATION: The 55-year-old male patient presented with several weeks of flu-like symptoms followed by jaundice, dyspnea, and progressive fatigue. Initial laboratory workup revealed hemolytic anemia, and subsequent serologic testing identified a warm autoantibody with anti-C specificity, but was ultimately consistent with an anti-e mediated WAIHA.

conclusionThis report highlights a complex case of a patient with an autoantibody mimicking anti-e associated WAIHA and the challenge of identifying suitable transfusion options.

Indexed as

AlloimmunizationAnemiaAutoantibodyAutoimmune hemolytic anemiaWarm autoimmune hemolytic anemia

Identifiers

PMID41824628
PMCPMC13584614

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