Evidence map›Paper›PMID 41824610›Full record

ArticleJACC. Case reports2026

Apolipoprotein A-IV Cardiac Amyloidosis Diagnosed by Mass Spectrometry-Based Proteomic Analysis.

Yu Masutani, Kenji Onoue, Tsunenari Soeda, Tomoya Nakano, Yasuhiro Sakaguchi, Jin Endo, Yukako Shintani-Domoto, Hiromitsu Kanamori, Fuyuki Kametani, Shungo Hikoso and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yu MasutaniDepartment of Internal Medicine, Nara General Medical Center, Nara, Japan; Department of Cardiovascular Medicine, Nara Medical University, Nara, Japan.
Kenji OnoueDepartment of Cardiovascular Medicine, Nara Medical University, Nara, Japan. Electronic address: konoue@naramed-u.ac.jp.
Tsunenari SoedaDepartment of Internal Medicine, Nara General Medical Center, Nara, Japan.
Tomoya NakanoDepartment of Cardiovascular Medicine, Nara Medical University, Nara, Japan.
Yasuhiro SakaguchiDepartment of Cardiovascular Medicine, Nara Medical University, Nara, Japan.
Jin EndoDepartment of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Yukako Shintani-DomotoDepartment of Diagnostic Pathology, Nippon Medical School, Bunkyō, Japan.
Hiromitsu KanamoriDepartment of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan.
Fuyuki KametaniDepartment of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Shungo HikosoDepartment of Cardiovascular Medicine, Nara Medical University, Nara, Japan.
Hiroyuki KawataDepartment of Internal Medicine, Nara General Medical Center, Nara, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundApolipoprotein A-IV amyloidosis (AApoA-Ⅳ) is a rare subtype of cardiac amyloidosis (CA) and is often overlooked because of its clinical similarity to transthyretin (ATTR) CA. CASE SUMMARY: An 82-year-old man presented with heart failure with preserved ejection fraction. His clinical features, including grade 1 uptake on DISCUSSION: Although the pathologic significance of the unique histologic features remains unclear, they may represent distinguishing characteristics of AApoA-IV amyloidosis. TAKE-HOME MESSAGES: AApoA-IV CA typically presents with elderly-onset heart failure with preserved ejection fraction and may show positive uptake on bone scintigraphy. Differentiation from ATTR CA is possible based on characteristic histopathologic findings and mass spectrometry-based proteomic analysis.

Indexed as

apolipoprotein A-IV cardiac amyloidosiselectron microscopyendomyocardial biopsymass spectrometry–based proteomic analysis

Identifiers

PMID41824610
PMCPMC13104368

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