Evidence map›Paper›PMID 41824527›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Biomimetic Ru-Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage.

Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhongxin DuanDepartment of Neurosurgery and Institute of Neurosurgical Research, State Key Laboratory of Biotherapy, West China Medical School, West China Hospital, Sichuan University, Chengdu, China.
Peng LiState Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Tianjian Laboratory of Advanced Biomedical Sciences, School of Convergence Medicine, Zhengzhou University, Zhengzhou, China.
Yue WangDepartment of Neurosurgery and Institute of Neurosurgical Research, State Key Laboratory of Biotherapy, West China Medical School, West China Hospital, Sichuan University, Chengdu, China.
Xin QiDepartment of Neurosurgery and Institute of Neurosurgical Research, State Key Laboratory of Biotherapy, West China Medical School, West China Hospital, Sichuan University, Chengdu, China.
Wanyu WangDepartment of Neurosurgery and Institute of Neurosurgical Research, State Key Laboratory of Biotherapy, West China Medical School, West China Hospital, Sichuan University, Chengdu, China.
Yongzhong ChengDepartment of Neurosurgery and Institute of Neurosurgical Research, State Key Laboratory of Biotherapy, West China Medical School, West China Hospital, Sichuan University, Chengdu, China.
Huabin ZhangDepartment of Neurosurgery and Neurosurgical Disease Research Centre, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Xin HuDepartment of Neurosurgery and Institute of Neurosurgical Research, State Key Laboratory of Biotherapy, West China Medical School, West China Hospital, Sichuan University, Chengdu, China.
Xiang GaoDepartment of Neurosurgery and Institute of Neurosurgical Research, State Key Laboratory of Biotherapy, West China Medical School, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0001-7478-5072

Funding

1·3·5 Project for Disciplines of Excellence, West China Hospital, Sichuan University ZYYC25008 ChinaNational Key Research and Development Program of China 2024YFA1210202the Sichuan Science and Technology Program 2023NSFSC1931
6 · The paper itself

Abstract

Intracerebral hemorrhage (ICH) is a lethal stroke subtype with limited treatment options, largely due to secondary injury driven by oxidative stress and neuroinflammation. Here, we developed a ruthenium (Ru)-manganese (Mn) composite nanozyme by integrating Ru nanozyme into Mn-doped zeolitic imidazolate framework (Mn-ZIF) to enable cascade catalytic activity for efficient ROS clearance. In vitro, Ru@Mn-ZIF nanozyme reduced LPS-induced microglia activation and H

Indexed as

Biomimetic MaterialsBrain InjuriesCerebral HemorrhageManganeseRutheniumAnimalsCatalysisDisease Models, AnimalMiceOxidative StressManganeseRutheniumintracerebral hemorrhagenanozymeneuroinflammationoxidative stressRu‐Mn composite

Identifiers

PMID41824527
PMCPMC13325807

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.