Evidence map›Paper›PMID 41824454›Full record

ArticleCell reports2026

CBP-IDRs regulate acetylation and gene expression.

Katie L Gelder, Nicola A Carruthers, Grace Gilbert, Laura J Harrison, Brychan V Evans, Thomas I Evans, Sophie S Ball, Mark Dunning, Timothy D Craggs, Alison E Twelvetrees and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Katie L GelderMolecular and Cellular Biology, School of Biosciences, The University of Sheffield, Sheffield S10 2TN, UK; Nucleic Acids Institute, The University of Sheffield, Sheffield S10 2TN, UK.
Nicola A CarruthersMolecular and Cellular Biology, School of Biosciences, The University of Sheffield, Sheffield S10 2TN, UK; Nucleic Acids Institute, The University of Sheffield, Sheffield S10 2TN, UK.
Grace GilbertMolecular and Cellular Biology, School of Biosciences, The University of Sheffield, Sheffield S10 2TN, UK; Nucleic Acids Institute, The University of Sheffield, Sheffield S10 2TN, UK; Neuroscience Institute, The University of Sheffield, Sheffield S10 2AH, UK.
Laura J HarrisonMolecular and Cellular Biology, School of Biosciences, The University of Sheffield, Sheffield S10 2TN, UK; Nucleic Acids Institute, The University of Sheffield, Sheffield S10 2TN, UK.
Brychan V EvansMolecular and Cellular Biology, School of Biosciences, The University of Sheffield, Sheffield S10 2TN, UK; Nucleic Acids Institute, The University of Sheffield, Sheffield S10 2TN, UK.
Thomas I EvansMolecular and Cellular Biology, School of Biosciences, The University of Sheffield, Sheffield S10 2TN, UK.
Sophie S BallMolecular and Cellular Biology, School of Biosciences, The University of Sheffield, Sheffield S10 2TN, UK.
Mark DunningNucleic Acids Institute, The University of Sheffield, Sheffield S10 2TN, UK; Neuroscience Institute, The University of Sheffield, Sheffield S10 2AH, UK; Sheffield Bioinformatics Core, Faculty of Health, The University of Sheffield, Sheffield S10 2HQ, UK.
Timothy D CraggsDepartment of Chemistry, School of Mathematical and Physical Sciences, Faculty of Science, The University of Sheffield, Sheffield S3 7HF, UK; Nucleic Acids Institute, The University of Sheffield, Sheffield S10 2TN, UK.
Alison E TwelvetreesDivision of Neuroscience, The School of Medicine and Population Health, Faculty of Health, The University of Sheffield, Sheffield S10 2HQ, UK; Neuroscience Institute, The University of Sheffield, Sheffield S10 2AH, UK.
Daniel A BoseMolecular and Cellular Biology, School of Biosciences, The University of Sheffield, Sheffield S10 2TN, UK; Nucleic Acids Institute, The University of Sheffield, Sheffield S10 2TN, UK. Electronic address: d.bose@sheffield.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrinsically disordered regions (IDRs) are essential regulators of protein function despite lacking stable secondary and tertiary structures. IDRs are integral to the function of multidomain regulatory proteins, such as the essential transcriptional coactivators cAMP response element-binding protein (CREB)-binding protein (CBP) and EP300 (p300), but how their multiple IDRs work together to regulate function remains poorly understood. Here, we demonstrate that different CBP-IDRs cooperate to control complex nuclear behaviors. We show how CBP-IDRs with different sequence properties make unique contributions to CBP behavior, establishing a critical balance between positive and negative regulation of CBP condensates. These opposing interactions are functionally important, tuning CBP's sensitivity to regulatory cues such as lysine acetylation. Disruption of this balance fundamentally alters CBP's chromatin occupancy, patterns of histone acetylation, and downstream gene expression. Together, our work reveals an unexpected mechanism of intramolecular cooperation between distinct IDRs and highlights how their properties shape the functional landscape of multi-domain proteins.

Indexed as

CREB-Binding ProteinGene Expression RegulationIntrinsically Disordered ProteinsAcetylationAnimalsChromatinE1A-Associated p300 ProteinHEK293 CellsHistonesHumansProtein BindingChromatinCREB-Binding ProteinCREBBP protein, humanE1A-Associated p300 ProteinHistonesIntrinsically Disordered Proteinsacetylationbiomolecular condensatesCBP/p300chromatinCP: molecular biologyenhancersgene regulationIDPsIDRsintrinsically disordered proteinstranscription

Identifiers

PMID41824454
PMCPMC13013760

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.