ArticlePacing and clinical electrophysiology : PACE2026
Prognostic Impact of the Atrial Fibrillation Burden in Patients With Pulmonary Embolism.
Article in Pacing and clinical electrophysiology : PACE, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe prognostic implications of atrial fibrillation (AF) burden in pulmonary embolism (PE) remains unclear. This study aimed to investigate the relationship between AF burden and prognosis in PE patients.
methodsIn this retrospective cohort study using the Medical Information Mart for Intensive Care IV (MIMIC-IV v2.0) database, patients with confirmed PE diagnosis were included. AF burden was calculated as the percentage of total AF duration relative to total records duration using nurse-documented continuous electronic monitoring (CEM) records. Patients with AF were dichotomized into low-burden and high-burden groups using an optimal cut-off value of 12.0%. Multivariable Cox proportional hazards models were employed to evaluate the 1-year all-cause mortality risk across sinus rhythm (SR), low-burden, and high-burden AF groups.
resultsAmong 1,175 patients, 246 (20.9%) had AF, comprising 84 cases of low-burden AF and 162 cases of high-burden AF. The 1-year all-cause mortality rates were 22.1% (SR), 26.2% (low-burden AF), and 40.7% (high-burden AF), respectively. After full adjustment, high-burden AF demonstrated a significant association with 1-year all-cause mortality (HR
conclusionsHigh AF burden independently predicted 1-year all-cause mortality in PE patients, suggesting its clinical utility for risk stratification.
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