Evidence map›Paper›PMID 41824213›Full record

ArticleAging clinical and experimental research2026

Usability and feasibility of INFORMA platform for computerized cognitive stimulation in mild cognitive impairment and early dementia: an 8-week multicenter study.

Cristina Basso, Andrea Zanella, Marco Simoni, Carlo Fantozzi, Donata Gollin, Cristina Ruaro, Silvia Tiozzo Netti, Alessandra Zapparoli, Roberta Padoan, Maurizio Gallucci and 14 more

Abstract readMulticenter Study
In one paragraph

Article in Aging clinical and experimental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Cristina BassoRegional Coordination Network for Neurodegenerative Diseases, Azienda Zero, Padova, Italy. cristina.basso@azero.veneto.it.
Andrea ZanellaDepartment of Information Engineering, University of Padova, Padova, Italy.
Marco SimoniRegional Brain Aging Center, University Hospital of Padova, Padova, Italy.
Carlo FantozziDepartment of Information Engineering, University of Padova, Padova, Italy.
Donata GollinRegional Brain Aging Center, University Hospital of Padova, Padova, Italy.
Cristina RuaroRegional Brain Aging Center, University Hospital of Padova, Padova, Italy.
Silvia Tiozzo NettiRegional Coordination Network for Neurodegenerative Diseases, Azienda Zero, Padova, Italy.
Alessandra ZapparoliDirectorate for Social Services, Veneto Region, Venice, Italy.
Roberta PadoanCognitive Impairment Center, Local Health Authority n. 1 Dolomiti, Belluno, Italy.
Maurizio GallucciCognitive Impairment Center, Local Health Authority n. 2, Marca Trevigiana, Treviso, Italy.
Livia GalloCognitive Impairment Center, Local Health Authority n. 3, Serenissima, Venice, Italy.
Luca ValentinisCognitive Impairment Center, Local Health Authority n. 4, Veneto Orientale, San Donà di Piave, Italy.
Moira CeciCognitive Impairment Center, Local Health Authority n. 5, Polesana, Rovigo, Italy.
Pierluigi Dal SantoCognitive Impairment Center, Local Health Authority n. 5, Polesana, Rovigo, Italy.
Anna CecconCognitive Impairment Center, Local Health Authority n. 6, Euganea, Padova, Italy.
Samantha PradelliCognitive Impairment Center, Local Health Authority n. 7, Pedemontana, Veneto, Italy.
Michela MarconCognitive Impairment Center, Local Health Authority n. 8, Berica, Vicenza, Italy.
Laura De TogniCognitive Impairment Center, Local Health Authority n. 9, Scaligera, Verona, Italy.
Anna Maria MussoCognitive Impairment Center, University Hospital of Verona, Verona, Italy.
Antonino RioloCentral Directorate of Health, Social Policies, Disabilities, FVG Region, Trieste, Italy.
Giuseppe GagniDirectorate for Social Services, Veneto Region, Venice, Italy.
Carlo GabelliRegional Brain Aging Center, University Hospital of Padova, Padova, Italy.
Pierangelo SpanoDirectorate for Social Services, Veneto Region, Venice, Italy.
Therapists Informa Group (TIG)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMild cognitive impairment (MCI) and dementia represent significant global health challenges requiring innovative intervention approaches. Computerized cognitive training (CCT) offers promising alternatives to traditional face-to-face interventions, providing flexibility and personalized care for individuals with cognitive disorders.

aimsThis study evaluated the usability of INFORMA, a novel software platform based on Cognitive Activation Therapy (CAT), for delivering telerehabilitation to participants with MCI and mild-to-moderate dementia.

methodsA prospective, non-interventional multicenter study enrolled 241 participants (MMSE 20-30, CDR 0.5-1) from 12 Italian Centers for Cognitive Disorders and Dementia. Participants engaged in an 8-week tablet-based telerehabilitation program with weekly supervision. Usability was assessed using the System Usability Scale (SUS), Task Completion Rate (TCR), and Relative Task Completion Time (R-TCT), supplemented by participant and caregiver questionnaires.

resultsOf 219 completing participants (mean age 73.5 years), the mean SUS score was 82.0 (95% CI: 80.3-83.8), with 84% exceeding the usability threshold (SUS score > 68). Mean TCR reached 97.8%, while 70.3% demonstrated improved R-TCT. Higher SUS scores correlated with education and MMSE scores but decreased with age. Satisfaction ratings exceeded 87% for participants and 95% for caregivers. DISCUSSION: INFORMA demonstrated high usability across all educational and cognitive levels, with the hybrid model combining automated exercises and professional supervision being well-received.

conclusionsINFORMA showed significant promise as a user-friendly computerized cognitive stimulation tool, supporting its potential efficacy for MCI and dementia interventions and warranting further therapeutic efficacy studies.

Indexed as

Cognitive DysfunctionDementiaAgedAged, 80 and overCognitive EnhancementCognitive TrainingFeasibility StudiesFemaleHumansMaleProspective StudiesSoftwareTelerehabilitation

Identifiers

PMID41824213
PMCPMC13005852

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.