Sinonasal Nonkeratinizing Squamous Cell Carcinoma with Synchronous Presence of HPV-High Risk and MKRN1::BRAF Fusion.

Diana Bell, Eric W Wang, Garret Choby, Carl Snyderman, Karunamurthy Arivarasan, Raja R Seethala

Abstract readCase Reports

In one paragraph

Article in Head and neck pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Diana BellDepartment of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA, 15213-2582, USA. bellmatesoid@upmc.edu.

Eric W WangDepartment of Otolaryngology/Skull Base, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Garret ChobyDepartment of Otolaryngology/Skull Base, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Carl SnydermanDepartment of Otolaryngology/Skull Base, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Karunamurthy ArivarasanDepartment of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA, 15213-2582, USA.

Raja R SeethalaDepartment of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA, 15213-2582, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An increased understanding of molecular alterations over the last decade has also impacted the landscape of sinonasal squamous cell carcinoma (SNSCC). In addition to traditional SCC risk factors (e.g. smoking) and high-risk HPV (HR- HPV), other drivers are emerging, such as DEK::AFF2 fusion in non-keratinizing and papillary SNSCC. Treatment of squamous cell carcinoma has been revolutionized with development of drugs that target key driver mutations and immune checkpoints. We describe a case report of nasal nonkeratinizing squamous cell carcinoma- HPV-high risk (HPV-HR) positive and harboring an MKRN1::BRAF fusion. We further discuss the significance of these findings, integrated in the context of current literature.

Indexed as

Carcinoma, Squamous CellPapillomavirus InfectionsParanasal Sinus NeoplasmsProto-Oncogene Proteins B-rafSquamous Cell Carcinoma of Head and NeckHuman Papillomavirus VirusesHumansBRAF protein, humanProto-Oncogene Proteins B-rafBRAF fusionsDriversHPV-HRSinonasal nonkeratinizing squamous cell carcinoma

Identifiers

PMID41824150

DOI10.1038/nature05610

PMCPMC12988105

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.