Evidence map›Paper›PMID 41824145›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2026

Mapping the neglected topic in head and neck paraganglioma research: a PRISMA scoping review on quality of life.

Djenghiz P S Samlal, Marina Hristova, Angelika Albrecht, Joerg Schipper, Thijs T G Jansen, Corinne P A Delsing, Henricus P M Kunst

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Djenghiz P S SamlalDepartment of Otolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands. djenghiz.samlal@radboudumc.nl.ORCID http://orcid.org/0000-0002-6708-2915
Marina HristovaDepartment of Otolaryngology and Head and Neck Surgery, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Angelika AlbrechtDepartment of Otolaryngology and Head and Neck Surgery, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Joerg SchipperDepartment of Otolaryngology and Head and Neck Surgery, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Thijs T G JansenDepartment of Otolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-4842-6954
Corinne P A DelsingDepartment of Otolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-7587-9791
Henricus P M KunstDepartment of Otolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-1162-6394

Funding

Interreg VI-program 33145
6 · The paper itself

Abstract

purposeParagangliomas in the head and neck (HNPGL) are rare slow growing neuro-endocrine tumors. The impact of various treatment strategies and tumor characteristics on health-related quality of life (HRQoL) remains unclear. This scoping review aims to map the available evidence and summarize the findings on how HNPGL affects patients’ HRQoL.

methodsA comprehensive literature search was conducted in PubMed, Embase, and Cochrane. Articles were included when presenting a quantification of HRQoL or Patient Reported Outcome Measures in patients with HNPGL (n ≥ 5). Studies focusing exclusively on paragangliomas outside the head and neck region were excluded. A scoping review using descriptive and inductive thematic analysis was performed and presented using the Prisma-ScR guidelines.

resultsFourteen studies were included presenting quantifiable HRQoL data in patients with HNPGL. The most used HRQoL measure were the Short Form-36 (n = 4, 29%) and EORTC Core Quality of Life questionnaire (QLQ-C30) (n = 3, 21%), followed by Short Form-12 (n = 2, 14%). HNPGL negatively affects HRQoL across several domains, even in patients not requiring an intervention. Specific subgroups, including those with carotid body tumors, multiple tumors, or dysphonia, reported disproportionately lower HRQoL.

conclusionCurrent sparse evidence on HRQoL in patients with HNPGL demonstrates significant impairment and identified various factors influencing this outcome. However, further research is necessary to specifically assess the effect of different therapeutic managements on HRQoL.

Indexed as

Head and Neck NeoplasmsParagangliomaQuality of LifeHumansSurveys and QuestionnairesCarotid bodyJugulotympanicParagangliomaQuality of lifeRadiotherapySurgery

Identifiers

PMID41824145
PMCPMC12987911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.