ArticleAnalytical and bioanalytical chemistry2026
Determination of fatty aldehydes in blood plasma and urine samples by dispersive solid-phase extraction followed by HPLC-FLD: evaluation as possible cancer biomarkers.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Mn-Fe bimetallic oxide-mediated photothermal immunoassay for portable screening of carcinoembryonic antigen.Analytical and bioanalytical chemistry · 2026Article
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4 authors.
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Abstract
Aldehydes have been primarily associated with certain types of cancer, making them potential biomarkers. This work focuses on the development of a sensitive extraction-derivatization methodology for the analysis of six aldehydes: pentanal, hexanal, heptanal, octanal, nonanal, and decanal in urine samples from control, smokers, and lung cancer patients as well as its possibility and prospects in blood plasma samples. Octyl-functionalized silica gel particles were used to extract aldehydes from the biological matrix, followed by derivatization of the analytes with 1-naphthalenyl hydrazine and analysis by HPLC-FLD. The methodology was optimized using a Plackett-Burman and central composite designs. Under optimal conditions found, calibration lines were constructed, obtaining limit of detections (LODs) in the interval of 0.55-0.80 µg L
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