Evidence map›Paper›PMID 41824016›Full record

ArticleSocial psychiatry and psychiatric epidemiology2026

Midlife exposure to neighborhood greenness and later-life cognitive decline: The Multi-Ethnic Study of Atherosclerosis.

Lilah M Besser, Lun-Ching Chang, Kelly R Evenson, James E Galvin, Susan R Heckbert, Jana A Hirsch, Peter James, Marcia Pescador Jimenez, Joel Kaufman, Samuel N Lockhart and 5 more

Abstract read
In one paragraph

Article in Social psychiatry and psychiatric epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Urban greenspace and dementia: Measures, mechanisms, and methodological guidance.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lilah M BesserComprehensive Center for Brain Health, Miller School of Medicine, University of Miami, 7700 W Camino Real, Suite 200, Boca Raton, FL, 33433, USA. lmb9767@miami.edu.
Lun-Ching ChangDepartment of Mathematics and Statistics, Florida Atlantic University, 777 Glades Road, SE43, Room 222, Boca Raton, FL, 33431, USA.
Kelly R EvensonDepartment of Epidemiology, Gillings School of Global Public Health, University of NC - Chapel Hill, 123 W. Franklin St, Building C Suite 410, CB #8050, Chapel Hill, NC, 27599-8050, USA.
James E GalvinComprehensive Center for Brain Health, Miller School of Medicine, University of Miami, 7700 W Camino Real, Suite 200, Boca Raton, FL, 33433, USA.
Susan R HeckbertDepartment of Epidemiology, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, WA, 98101, USA.
Jana A HirschDepartment of Epidemiology and Biostatistics, Dornsife School of Public Health, Urban Health Collaborative, Drexel University, 3600 Market St, Room 706, Philadelphia, PA, 19104, USA.
Peter JamesDepartment of Public Health Sciences, University of California Davis School of Medicine, Davis, CA, 95616, USA.
Marcia Pescador JimenezDepartment of Epidemiology, Boston University School of Public Health, 02118, Boston, MA, USA.
Joel KaufmanDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Box 351618, Seattle, WA, 98195, USA.
Samuel N LockhartDepartment of Internal Medicine, Medical Center Blvd, Wake Forest University of School of Medicine, Winston-Salem, NC, 27157, USA.
Diana MitsovaDepartment of Urban and Regional Planning, Florida Atlantic University, 777 Glades Road, SO-273, Boca Raton, FL, 33431, USA.
Kari A MooreDornsife School of Public Health, Urban Health Collaborative, Drexel University, 3600 Market St, Philadelphia, PA, 19104, USA.
Bonnie C SachsDepartment of Neurology, Wake Forest School of Medicine, NC, Winston- Salem, 27157, USA.
Timothy HughesDepartment of Internal Medicine, Medical Center Blvd, Wake Forest University of School of Medicine, Winston-Salem, NC, 27157, USA.
Ana V Diez RouxDornsife School of Public Health, Urban Health Collaborative, Drexel University, 3600 Market St, Philadelphia, PA, 19104, USA.

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Subclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)R01AG058969 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Timothy M. Hughes, YONGMEI LIU · 2018 to 2026
$33.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
Wake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BAKER, LAURA D. · 2016 to 2020
$12.2M
Atrial fibrillation burden, vascular disease of the brain and cardiac MRI in MESAR01HL127659 · NHLBI · UNIVERSITY OF WASHINGTON · PI HECKBERT, SUSAN R · 2015 to 2018
$7.4M
Longitudinal Neighborhood Determinants of ADRD Progression within a Multi-Site CohortR01AG072634 · NIA · DREXEL UNIVERSITY · PI Jana Ariel Hirsch · 2021 to 2026
$6.1M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Neighborhoods and CVD Risk in a Multiethnic Cohort (RMI)R01HL071759 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIEZ ROUX, ANA VICTORIA · 2003 to 2013
$4.8M
TO EXERCISE OPTION PERIOD ONE (1) FOR TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.75N92020D00004 · NHLBI · NORTHWESTERN UNIVERSITY · PI SIEGEL, JONATHAN H · 2020 to 2025
$4.5M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL071759NHLBI NIH HHS R01 HL127659NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG072947NIA NIH HHS R00 AG066949NIA NIH HHS R01 AG054069NIA NIH HHS R01 AG058969NIA NIH HHS R01 AG072634NIA NIH HHS R01 AG087199NIA NIH HHS R21 AG075291NIH HHS R21AG075291
6 · The paper itself

Abstract

purposeWe investigated whether living in greener neighborhoods in midlife is associated with slower cognitive decline in later life.

methodsWe used data on 2,881 participants from the population-based Multi-Ethnic Study of Atherosclerosis. Geocoded residential addresses (1980–2009) were used to derive midlife neighborhood greenness exposure defined as a 10-year mean of annual normalized difference vegetation index values (based on satellite imagery) during the midlife period (ages 45–54). Cognitive testing over ~ 10 years, when the participants were ≥ 55-year-olds, captured global cognition and processing speed. Multivariable linear mixed effects regression estimated associations between the 10-year midlife greenness measure and global cognition and processing speed z-scores in later life and whether greenness-cognition associations varied by age at first cognitive visit.

resultsGreater midlife greenness was associated with slower annual decline in processing speed in the overall sample. We found no differences in associations by age at first cognitive visit.

conclusionIn an ethnoracially and geographically diverse US cohort, living in greener neighborhoods in midlife was associated with slower cognitive decline (i.e., processing speed) in later life.

Indexed as

CognitionCognitive declineGreennessGreenspaceMidlifeNeighborhood

Identifiers

PMID41824016
PMCPMC13409554

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