ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Effects of combined dietary fiber and probiotic supplementation on gut microbiota, immune function, and clinical outcomes in patients with advanced colorectal cancer: a retrospective cohort study.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Funding
Abstract
objectiveTo evaluate the efficacy of a combined intervention of dietary fiber and probiotics on gut microbiota composition, systemic immune response, nutritional status, and long-term prognosis in patients with advanced colorectal cancer (CRC) undergoing conventional therapy.
methodsThis retrospective cohort study included 80 patients with advanced CRC and diagnosed malnutrition, treated between May and December 2022. Patients were divided into a control group (n = 40), which received standard nutritional support, and an observation group (n = 40), which received standard support supplemented with a daily formulation of dietary fiber and multi-strain probiotics for 12 weeks. Primary endpoints included changes in immune markers (IgA, IgG, CD4+/CD8+ ratio) and gut microbiota composition (alpha and beta diversity, and specific genera abundance via 16S rRNA sequencing). Secondary endpoints were nutritional status (body mass index [BMI], Patient-Generated Subjective Global Assessment [PG-SGA]), quality of life (WHOQOL-100), and 3-year survival outcomes.
resultsBaseline characteristics were well-matched between groups (p > 0.05). After 12 weeks, the observation group exhibited significantly higher levels of IgA (0.95 ± 0.24 vs. 0.78 ± 0.15 g/L), IgG (9.34 ± 1.35 vs. 8.05 ± 1.16 g/L), and an improved CD4+/CD8+ ratio (2.18 ± 0.20 vs. 1.56 ± 0.15) compared to the control group (all p < 0.01). The intervention led to superior improvements in BMI (+ 2.83 kg/m
conclusionIn patients with advanced CRC, supplementing conventional therapy with dietary fiber and probiotics effectively modulates the gut microbiota, enhances systemic immune function, improves nutritional status and quality of life, and is associated with better long-term survival. These findings advocate for the integration of gut microbiota-targeted nutritional strategies into standard oncological care.
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