Evidence map›Paper›PMID 41823943›Full record

ArticleJACC. Clinical electrophysiology2026

Combined Analysis of Cardiac Repolarization Entropy and Magnetic Resonance Imaging Enhances Risk Stratification of Patients Receiving a Primary-Prevention ICD.

Tanmay A Gokhale, Swati Dey, Worawan B Limpitikul, Nitesh Gautam, Subhi J Al'Aref, Brian Cross, Samir Saba, N A Mark Estes, Benjamin L Vaughan, Steven R Jones and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Clinical electrophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tanmay A GokhaleHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; Global Engineering Network for Intelligent Unified Healthcare Solutions, McGowan Institute for Regenerative Medicine and Carnegie Mellon University, Pittsburgh, Pennsylvania, USA; Division of Cardiology, Department of Internal Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; Section of Cardiac Electrophysiology, Division of Cardiology, Department of Internal Medicine, Veterans Affairs Pittsburgh Health System, Pittsburgh, Pennsylvania, USA; Veterans Health Foundation, Pittsburgh, Pennsylvania, USA.
Swati DeyGlobal Engineering Network for Intelligent Unified Healthcare Solutions, McGowan Institute for Regenerative Medicine and Carnegie Mellon University, Pittsburgh, Pennsylvania, USA; Section of Cardiac Electrophysiology, Division of Cardiology, Department of Internal Medicine, Veterans Affairs Pittsburgh Health System, Pittsburgh, Pennsylvania, USA; Veterans Health Foundation, Pittsburgh, Pennsylvania, USA; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Worawan B LimpitikulDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Nitesh GautamDivision of Cardiology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Subhi J Al'ArefDivision of Cardiology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Brian CrossSection of Cardiac Electrophysiology, Division of Cardiology, Department of Internal Medicine, Veterans Affairs Pittsburgh Health System, Pittsburgh, Pennsylvania, USA; Veterans Health Foundation, Pittsburgh, Pennsylvania, USA.
Samir SabaHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; Division of Cardiology, Department of Internal Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
N A Mark EstesHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; Division of Cardiology, Department of Internal Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Benjamin L VaughanGlobal Engineering Network for Intelligent Unified Healthcare Solutions, McGowan Institute for Regenerative Medicine and Carnegie Mellon University, Pittsburgh, Pennsylvania, USA; Section of Cardiac Electrophysiology, Division of Cardiology, Department of Internal Medicine, Veterans Affairs Pittsburgh Health System, Pittsburgh, Pennsylvania, USA; Veterans Health Foundation, Pittsburgh, Pennsylvania, USA; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Steven R JonesGlobal Engineering Network for Intelligent Unified Healthcare Solutions, McGowan Institute for Regenerative Medicine and Carnegie Mellon University, Pittsburgh, Pennsylvania, USA; Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Gordon F TomaselliDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Albert Einstein College of Medicine and Montefiore Medicine, New York, New York, USA.
Katherine C WuDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Deeptankar DeMazumderHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; Global Engineering Network for Intelligent Unified Healthcare Solutions, McGowan Institute for Regenerative Medicine and Carnegie Mellon University, Pittsburgh, Pennsylvania, USA; Division of Cardiology, Department of Internal Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; Section of Cardiac Electrophysiology, Division of Cardiology, Department of Internal Medicine, Veterans Affairs Pittsburgh Health System, Pittsburgh, Pennsylvania, USA; Veterans Health Foundation, Pittsburgh, Pennsylvania, USA; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: deeptankar@pitt.edu.

Funding

Training Program in Imaging Sciences in Translational Cardiovascular ResearchT32HL129964 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Flordeliza S Villanueva · 2016 to 2026
$4.7M
Fundamental Biology of SCD and its Application to Identify Patients at RiskR01HL091062 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TOMASELLI, GORDON FRANK · 2009 to 2013
$3.4M
Cardiac MR to Improve Clinical Risk Prediction in Defibrilator PatientsR01HL132181 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TOMASELLI, GORDON FRANK, WU, KATHERINE C · 2017 to 2020
$3.1M
Eavesdropping on heart-brain conversations during sleep for early detection and prevention of fatal cardiovascular diseaseDP2HL157941 · NHLBI · VETERANS HEALTH FOUNDATION · PI DEMAZUMDER, DEEPTANKAR · 2020 to 2020
$2.4M
LV Structural Predictors of Sudden Cardiac DeathR01HL103812 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WU, KATHERINE C · 2010 to 2013
$1.4M
Autonomic remodeling and modulation therapy in heart failure and sudden deathR00HL130662 · NHLBI · UNIVERSITY OF CINCINNATI · PI DEMAZUMDER, DEEPTANKAR · 2017 to 2019
$747k
Autonomic remodeling and modulation therapy in heart failure and sudden deathK99HL130662 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI DEMAZUMDER, DEEPTANKAR · 2016 to 2016
$172k
NHLBI NIH HHS DP2 HL157941NHLBI NIH HHS K99 HL130662NHLBI NIH HHS L30 HL115782NHLBI NIH HHS R00 HL130662NHLBI NIH HHS R01 HL091062NHLBI NIH HHS R01 HL103812NHLBI NIH HHS R01 HL132181NHLBI NIH HHS T32 HL129964
6 · The paper itself

Abstract

backgroundAccurate selection of patients who will benefit from a primary-prevention implantable cardioverter-defibrillator (ICD) remains a challenge. Cardiac magnetic resonance imaging (CMR) of myocardial tissue heterogeneity and EntropyX

objectivesBecause CMR and EntropyX

methodsIn 230 consecutive patients with a left ventricular ejection fraction ≤35% in sinus rhythm, baseline exposures before primary prevention ICD implantation included demographics, history, medications, laboratory results, conventional ECG indices of heart rate and QT variability, CMR myocardial tissue characterization, and EntropyX

resultsOver 6.1 ± 3.3 years of follow-up, 62 patients (27%) received appropriate ICD shocks. In multivariable analyses, EntropyX

conclusionsEntropyX

Indexed as

Death, Sudden, CardiacDefibrillators, ImplantableMagnetic Resonance ImagingPrimary PreventionAgedElectrocardiographyEntropyFemaleHumansMaleMiddle AgedRisk AssessmentTachycardia, Ventricularfibrosisheart failureimplantable cardioverter-defibrillatorsudden cardiac arrestventricular tachyarrhythmia

Identifiers

PMID41823943
PMCPMC13283008

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.