Evidence map›Paper›PMID 41823912›Full record

ArticleJACC. Case reports2026

Insight Into the Multifactorial Nature of Platypnea-Orthodeoxia Syndrome: Not Just a Solo.

Gabriele De Palma, Rosaria Barracano, Nunzia Borrelli, Mario Giordano, Giuseppe Paone, Federica Lo Presti, Rosa Cauteruccio, Giancarlo Scognamiglio, Alessandro Della Corte, Berardo Sarubbi

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gabriele De PalmaUniversity of Campania Luigi Vanvitelli, Naples, Italy; Adult Congenital Heart Disease and Congenital and Familial Arrhythmias Unit, Monaldi Hospital, Naples, Italy.
Rosaria BarracanoAdult Congenital Heart Disease and Congenital and Familial Arrhythmias Unit, Monaldi Hospital, Naples, Italy.
Nunzia BorrelliAdult Congenital Heart Disease and Congenital and Familial Arrhythmias Unit, Monaldi Hospital, Naples, Italy.
Mario GiordanoPediatric Cardiology Unit, Monaldi Hospital, Naples, Italy.
Giuseppe PaoneDepartment of Translational Medical Sciences, Cardiac Surgery Unit, University of Campania Luigi Vanvitelli, Naples, Italy.
Federica Lo PrestiDepartment of Translational Medical Sciences, Cardiac Surgery Unit, University of Campania Luigi Vanvitelli, Naples, Italy.
Rosa CauteruccioDepartment of Respiratory Pathophysiology and Rehabilitation, Monaldi Hospital, Naples, Italy.
Giancarlo ScognamiglioAdult Congenital Heart Disease and Congenital and Familial Arrhythmias Unit, Monaldi Hospital, Naples, Italy.
Alessandro Della CorteDepartment of Translational Medical Sciences, Cardiac Surgery Unit, University of Campania Luigi Vanvitelli, Naples, Italy.
Berardo SarubbiAdult Congenital Heart Disease and Congenital and Familial Arrhythmias Unit, Monaldi Hospital, Naples, Italy; University of Naples Parthenope, Naples, Italy. Electronic address: berardo.sarubbi@ospedalideicolli.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlatypnea-orthodeoxia syndrome (POS) is a rare condition with complex pathophysiology resulting from an anatomical site of shunting, mostly a patent foramen ovale (PFO), and factors promoting a right-to-left (R-L) shunt. CASE SUMMARY: A 54-year-old man was referred to our center for unexplained respiratory failure, exacerbated by sitting. A suspicion of POS was raised, and transesophageal echocardiography demonstrated a wide stretched PFO with R-L shunting, related to the presence of an aortic root aneurysm and right hemidiaphragm elevation, both compressing the right atrium, as well as a prominent eustachian valve. The patient underwent valve-sparing aortic root replacement and concomitant PFO closure, with resolution of symptoms. TAKE-HOME MESSAGES: Multiple factors promoting R-L shunt have been associated with POS. The treatment of choice is represented by the correction of the anatomical shunt. Multidisciplinary team discussion is paramount for the diagnosis and management of this complex condition.

Indexed as

ascending aorta aneurysmhemidiaphragm elevationpatent foramen ovaleplatypnea-orthodeoxia syndrome

Identifiers

PMID41823912
PMCPMC13104366

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.