Evidence map›Paper›PMID 41823834›Full record

ArticleBiology2026

Genetic Activation of Locus Coeruleus Noradrenergic Neurons Modulates Cerebellar MF-GrC Synaptic Plasticity via Presynaptic α2-AR/PKA Signaling in Mice.

Ying-Han Xu, Xu-Dong Zhang, Yang Liu, Zhi-Zhi Zhao, Yuan Zheng, De-Lai Qiu, Chun-Ping Chu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ying-Han XuDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji 133002, China.
Xu-Dong ZhangDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji 133002, China.
Yang LiuDepartment of Neural Circuit, Brain Science Institute, Jilin Medical University, Jilin 132013, China.ORCID 0009-0008-7631-4440
Zhi-Zhi ZhaoDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji 133002, China.
Yuan ZhengDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji 133002, China.
De-Lai QiuDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji 133002, China.
Chun-Ping ChuDepartment of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji 133002, China.ORCID 0009-0006-6921-5028

Funding

the Major Projects of the Ministry of Science and Technology of China 2021ZD0202300the National Natural Science Foundations of China 32171005the Science and technology development plan project of Jilin Province, China JJKH20261242KJ
6 · The paper itself

Abstract

Locus coeruleus (LC) noradrenergic neurons project their axons to the cerebellar cortex and modulate cerebellar circuit function via distinct adrenergic receptor (AR) subtypes. The present study investigated the mechanism by which optogenetic activation of LC noradrenergic neurons modulates facial stimulation-evoked long-term synaptic plasticity at cerebellar mossy fiber-granule cell (MF-GrC) synapses in urethane-anesthetized DBH-Cre mice. Blockade of GABA

Indexed as

cerebellumfacial stimulationglutamate sensor iGluSnFRlocus coeruleuslong-term plasticitymossy fiber-granule cell synapseoptogenetic and chemogenetic activationprotein kinase Aα2-adrenergic receptor

Identifiers

PMID41823834
PMCPMC12984717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.