Evidence map›Paper›PMID 41823605›Full record

ArticleRadiology. Imaging cancer2026

Automated Cluster-based Quantitative Analysis of Ultrafast DCE MRI for Differential Breast DCIS Grading.

Zhen Ren, Xiaobing Fan, Saengsiri Chumsaengsri, Milica Medved, Hiroyuki Abe, Kirti Kulkarni, Hyunji Shim, Gregory S Karczmar

Abstract read
In one paragraph

Article in Radiology. Imaging cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Zhen RenDepartment of Radiology, The University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637.ORCID 0000-0002-2262-4880
Xiaobing FanDepartment of Radiology, The University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637.
Saengsiri ChumsaengsriDepartment of Radiology, The University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637.
Milica MedvedDepartment of Radiology, The University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637.ORCID 0000-0003-2945-5511
Hiroyuki AbeDepartment of Radiology, The University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637.ORCID 0000-0002-3568-1462
Kirti KulkarniDepartment of Radiology, The University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637.
Hyunji ShimDepartment of Radiology, The University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637.
Gregory S KarczmarDepartment of Radiology, The University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637.ORCID 0000-0002-2455-5858

Funding

The Funding Mechanism of the Pilot TrialR01CA276652 · NCI · UNIVERSITY OF CHICAGO · PI Hiroyuki Abe, Gregory S. Karczmar · 2023 to 2026
$5.0M
Quantitative MRI for Predicting Response of Breast Cancer to Neoadjuvant TherapyU01CA142565 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KARCZMAR, GREGORY S., NANDA, RITA · 2010 to 2019
$4.5M
Quantitative DCEMRI of Prostate Cancer Correlation with Gold StandardsR01CA172801 · NCI · UNIVERSITY OF CHICAGO · PI KARCZMAR, GREGORY S., OTO, AYTEKIN · 2013 to 2017
$2.3M
NCI NIH HHS R01 CA172801NCI NIH HHS R01 CA276652NCI NIH HHS U01 CA142565
6 · The paper itself

Abstract

Purpose To assess whether k-means clustering (KMC) analysis of ultrafast dynamic contrast-enhanced (DCE) MRI kinetics can help differentiate ductal carcinoma in situ (DCIS) grades and identify aggressive lesions. Materials and Methods In this retrospective study of patients with DCIS who underwent ultrafast DCE MRI (3.0-9.0 seconds per image) between May 2015 and September 2024, KMC was performed to classify the breast parenchyma, including lesion voxels, into five clusters regarding maximum slope (

Indexed as

Breast NeoplasmsCarcinoma, Intraductal, NoninfiltratingDynamic Contrast Enhanced Magnetic Resonance ImagingAdultCluster AnalysisContrast MediaDiagnosis, DifferentialFemaleHumansMiddle AgedNeoplasm GradingRetrospective StudiesContrast MediaDuctal Carcinoma in situ Gradingk-Means ClusteringUltrafast Dynamic Contrast-enhanced MRI

Identifiers

PMID41823605
PMCPMC13036653

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.