Evidence map›Paper›PMID 41823560›Full record

ArticleOncology reports2026

Silencing of SIVA‑1 promotes cisplatin resistance in gastric cancer via the Bcl‑2/BAX‑mediated mitochondria‑dependent apoptosis pathway.

Zheng-Yi Shi, Zheng-Rong Ding, Yu-Liang Huang, Yuan-Rui Lei, Hai-Bin Huang, Yan Qing, Miao-Ren Deng, Xu-Man Lu, Xu-Dong Dong, Long-Jie Xia and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zheng-Yi Shi *Department of Colorectal and Anal Surgery, People's Hospital of Guangxi Zhuang Autonomous Region and Institute of Minimally Invasive Technology and Applications, Guangxi Academy of Medical Sciences, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.
Zheng-Rong Ding *The Tenth Clinical Medical College of Guangzhou University of Traditional Chinese Medicine, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, Guangdong 528400, P.R. China.
Yu-Liang HuangDepartment of Colorectal and Anal Surgery, People's Hospital of Guangxi Zhuang Autonomous Region and Institute of Minimally Invasive Technology and Applications, Guangxi Academy of Medical Sciences, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.
Yuan-Rui LeiGraduate School, Guangxi Medical University, Nanning, People's Republic of China, Guangxi Zhuang Autonomous Region 530021, P.R. China.
Hai-Bin HuangDepartment of Colorectal and Anal Surgery, People's Hospital of Guangxi Zhuang Autonomous Region and Institute of Minimally Invasive Technology and Applications, Guangxi Academy of Medical Sciences, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.
Yan QingDepartment of Colorectal and Anal Surgery, People's Hospital of Guangxi Zhuang Autonomous Region and Institute of Minimally Invasive Technology and Applications, Guangxi Academy of Medical Sciences, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.
Miao-Ren DengDepartment of Colorectal and Anal Surgery, People's Hospital of Guangxi Zhuang Autonomous Region and Institute of Minimally Invasive Technology and Applications, Guangxi Academy of Medical Sciences, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.
Xu-Man LuDepartments of Gastrointestinal, Hernia and Enterofistula Surgery, People's Hospital of Guangxi Zhuang Autonomous Region and Institute of Minimally Invasive Technology and Applications, Guangxi Academy of Medical Sciences, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.
Xu-Dong DongDepartment of Colorectal and Anal Surgery, People's Hospital of Guangxi Zhuang Autonomous Region and Institute of Minimally Invasive Technology and Applications, Guangxi Academy of Medical Sciences, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.
Long-Jie XiaDepartment of Cosmetic Plastic Surgery, People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.
Sheng XuDepartments of Gastrointestinal, Hernia and Enterofistula Surgery, People's Hospital of Guangxi Zhuang Autonomous Region and Institute of Minimally Invasive Technology and Applications, Guangxi Academy of Medical Sciences, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.
Xiao-Gang ZhongDepartments of Gastrointestinal, Hernia and Enterofistula Surgery, People's Hospital of Guangxi Zhuang Autonomous Region and Institute of Minimally Invasive Technology and Applications, Guangxi Academy of Medical Sciences, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.
Lei LiDepartments of Gastrointestinal, Hernia and Enterofistula Surgery, People's Hospital of Guangxi Zhuang Autonomous Region and Institute of Minimally Invasive Technology and Applications, Guangxi Academy of Medical Sciences, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.
Fan-Biao KongDepartment of Colorectal and Anal Surgery, People's Hospital of Guangxi Zhuang Autonomous Region and Institute of Minimally Invasive Technology and Applications, Guangxi Academy of Medical Sciences, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.
Xiao-Tong WangDepartments of Gastrointestinal, Hernia and Enterofistula Surgery, People's Hospital of Guangxi Zhuang Autonomous Region and Institute of Minimally Invasive Technology and Applications, Guangxi Academy of Medical Sciences, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present study was to investigate the effects of SIVA‑1 silencing on the drug resistance and biological functions of cisplatin (DDP)‑resistant human gastric cancer cells (AGS/DDP), and to explore the mechanism underlying its occurrence. AGS/DDP cells with stable silencing of SIVA‑1 were established by molecular biology techniques. The Cell Counting Kit‑8 assay was used to investigate the effect of SIVA‑1 silencing on drug sensitivity in AGS/DDP cells by measuring the IC

Indexed as

CisplatinDrug Resistance, NeoplasmStomach NeoplasmsAnimalsAntineoplastic AgentsApoptosisApoptosis Regulatory Proteinsbcl-2-Associated X ProteinCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticGene SilencingHumansMaleMiceAntineoplastic AgentsApoptosis Regulatory ProteinsBAX protein, humanbcl-2-Associated X ProteinBCL2 protein, humanCisplatinProto-Oncogene Proteins c-bcl-2SIVA1 protein, humanBcl‑2bioinformatics analysisdrug resistancegastric cancerSIVA‑1

Identifiers

PMID41823560
PMCPMC13034405

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.